New levels (as yet unnamed) Escalating risk of serious adverse event Physiological monitoring parameters (singular or combination)a Recommended sedationist skill set Recommended resourcesb 1 ≤1:10,000 Consistent with normal awake pattern…
Symptom Prevalence Fatigue 83 % Dyspnea 50–63 % Malaise/restlessness 40 % Pain 25–48 % Confusion 36 % Anxiety 31 % Depression 28 % Agitation 21 % Nausea/vomiting 6–25 % More…
Reported practices Associated potentially serious consequences • Unmonitored PSA during magnetic resonance imaging (MRI) • Not discovering in time potentially dangerous side effects (respiratory depression, hypoxia or bradycardia) • No formal monitoring, observation,…
Fig. 33.1 The translational pathway The focus on translation is due to the ever-increasing research budgets in the face of stubbornly stable global or national health indices. Research that has…
Fig. 15.1 Assessment, complementary interventions, pharmacological treatment, and effective implementation fit together like puzzle pieces for the effective management of pain in neonates Assessment of Distress and Pain in Neonates…
Provider must be qualified and credentialed Provider must have skills to rescue patient Provider must have knowledge of medications and potential complications Provider must prepare for a deeper level of…
Drug Neurotoxicity/altered plasticity Reference Propofol Yes [10, 11, 19, 26, 40, 42] Midazolam Yes [11, 18] Pentobarbital Yes [26] Chloral hydrate Yes [29, 54] Ketamine Yes [8, 11, 27, 33,…
Fig. 26.1 Phases of drug development. NDA New Drug Application, IND Investigational New Drug Application Initial studies in humans (Phase 1 trials) are the first stage of testing in human…
Brief: <10 min Intermediate: 10–20 min Extended: >20 min Adapted from Green SM, Roback MG, Miner JR, Burton JH, Krauss B. Fasting and Emergency Department Procedural Sedation and Analgesia: A…
Fig. 24.1 Staffing requirements for procedural sedation and analgesia in Australia and New Zealand. Reprinted with permission from Australian and New Zealand College of Anaesthetists. Guidelines on Sedation and/or Analgesia…
