Principles of Neonatal Pharmacology
Principles of Neonatal Pharmacology Jeffrey L. Blumer Michael D. Reed Introduction The history of drug therapy is replete with examples of adverse reactions to drugs in children. Virtually all the…
Maternal Drug Intake and the Newborn
Maternal Drug Intake and the Newborn Nada Djokanovic Rada Boskovic Gideon Koren Introduction The use of prescription drugs during pregnancy has become a concern since the thalidomide tragedy. However, medication…
Biotransformation of Medications by Human Placenta
Biotransformation of Medications by Human Placenta Olga Zharikova Tatiana Nanovskaya Mahmoud S. Ahmed Introduction Human placenta is a tissue of fetal origin located at the interface between the maternal and…
Developmental Toxicology
Developmental Toxicology Donald R. Mattison Introduction The United States has made progress in maternal and infant health (1,2,3,4); infant mortality has fallen (Fig. 11.1) as a consequence of pediatric nutrition,…
Drug Formulations
Drug Formulations Milap C. Nahata A continuing decline in the morbidity and mortality in the pediatric population can be attributed, in part, to the availability of effective drugs for preventing…
Therapeutic Drug Monitoring
Therapeutic Drug Monitoring Alexander A. Vinks Philip D. Walson Introduction The simplest way to identify interindividual variability in drug response is to objectively measure the degree of effect and then…
Ethics of Drug Research in Pediatric Populations
Ethics of Drug Research in Pediatric Populations Bruce A. Russell Sanford N. Cohen Virginia Delaney-Black Why Research on Children is Needed The majority of pharmacologic agents and pharmaceutical preparations currently…
Clinical Trials Involving Children: History, Rationale, Regulatory Framework, and Technical Considerations
Clinical Trials Involving Children: History, Rationale, Regulatory Framework, and Technical Considerations Steven Hirschfeld Brief History of Research Involving Children Children have been utilized to test new therapies for thousands of…
Adherence with Pediatric Medication Regimens
Adherence with Pediatric Medication Regimens Hakan Ergün Daniel A.C. Frattarelli Doreen Matsui Introduction In pharmacotherapy, the terms “compliance” and “adherence” are often used interchangeably, although the latter term is preferred…
Pharmacogenetics, Pharmacogenomics, and Pharmacoproteomics
Pharmacogenetics, Pharmacogenomics, and Pharmacoproteomics J. Steven Leeder Introduction It is readily accepted that genetic factors play an important role in influencing a child’s potential physical characteristics such as height, weight,…
