Management of CKD in Infancy
Management of CKD in Infancy Infant CKD is a complex condition requiring intensive, specialized management to avoid the many complications of renal insufficiency and promote normal growth and development. Management…
Nonsteroidal Antiinflammatory Agents
Nonsteroidal Antiinflammatory Agents Vasoactive forms of nonsteroidal antiinflammatory agents such as indomethacin, aspirin and ibuprofen can induce renal hypoperfusion in neonates, especially preterm neonates, resulting in usually reversible, oliguric ARF…
Nephrotoxicity
Nephrotoxicity Several agents that cross the placenta (see Chapter 15) can damage the fetal kidney, including aminoglycosides, ACE inhibitors, heavy metals, and organic solvents (Table 42-10) (579). Chapters 15 and…
Acute Renal Failure and Oligoanuria
Acute Renal Failure and Oligoanuria ARF, usually defined as an acute deterioration in the ability of the kidneys to maintain the homeostasis of body fluids (449), is associated with an…
Physical Examination
Physical Examination Dysmorphism Renal and Urinary Tract Anomalies Associated with Multiple Congenital Anomalies Any dysmorphic feature (e.g., abnormal ears) should lead the clinician to look for other anomalies and structural…
Clinical Evaluation of Renalfunction and Disease
Clinical Evaluation of Renalfunction and Disease Early diagnosis of a renal anomaly may help to prevent complications, including those related to the kidney itself (e.g., progressive loss of renal function…
Developmental Physiology
Developmental Physiology The kidneys play a central role in the physiologic transition from fetal to postnatal life. Whereas homeostasis in utero is maintained largely by the placenta, adaptation to the…
Inherited Metabolic Disorders
Inherited Metabolic Disorders Barbara K. Burton Major advances in the recognition and treatment of inborn errors of metabolism have made it more essential than ever that the neonatologist be familiar…
Gastrointestinal Disease
Gastrointestinal Disease Jon A. Vanderhoof Terence L. Zach Thomas E. Adrian Although most pediatric gastroenterologists are uncomfortable with primary care of the sick premature infant, they often are valuable consultants…
