Corticosteroids
Budesonide n = 22 Prednisolone n = 26a p-value Moon face 5 15 0.01 Buffalo hump 0 1 NS Acne 1 7 0.033 Hirsutism 2 3 NS Skin striae…
PEDIATRICS
Nutritional Management of Inflammatory Bowel Disease
3. Kanof ME, Lake AM, Bayless TM. Decreased height velocity in children and adolescents before the diagnosis of Crohn’s disease. Gastroenterology. 1988;95(6):1523–7.PubMed 4. Levine A, et al. Consensus and controversy…
Antibiotic Therapy
2. Rutgeerts P, Goboes K, Peeters M, et al. Effect of faecal stream diversion on recurrence of Crohn disease in the neoterminal ileum. Lancet. 1991;338:771–4.PubMedCrossRef 3. Perencevich M, Burakoff R….
Inflammatory Bowel Diseases and Skeletal Health
Fig. 13.1 Bone modeling and remodeling. Bone modeling occurs uniquely in children and results from the combined activities of osteoblasts, osteoclasts and the growth plate cells. Its result is bone…
Extraintestinal Manifestations of Pediatric Inflammatory Bowel Disease
Extraintestinal manifestation Prevalence Growth failure ++++ Sacroiliitis ++++ Osteoporosis/osteopenia +++ Peripheral joint inflammation +++ Aphtous lesions +++ Primary sclerosing cholangitis ++ Granulomatous skin lesion ++ Erythema nodosum ++ Pyoderma gangrenosum…
Laboratory Evaluation of Inflammatory Bowel Disease
Test Findings Significance Complete blood count and differential Anemia (microcytic, macrocytic, normocytic), thrombocytosis, leukocytosis Anemia: Assess severity of blood loss, evaluate for iron and other macronutrient deficiencies. Reported prevalence 16–77%…
The History and Physical Exam
Wisconsin N = 199 Great Britain N = 739 UC (%) CD (%) UC n = 172 (%) IC n = 72 (%) CD n = 379 (%) Abdominal…
Differential Diagnosis of Inflammatory Bowel Disease
Laboratory test Organism suggested or identified Microscopic stool examination Fecal leukocytes Invasive or cytotoxin-producing bacteria Trophozoïtes, cysts, oocysts, or spores Giardia lamblia, Entameoba histolytica, Schistosoma mansoni Spiral or S-shapped gram-negative…
Epidemiology of Pediatric Inflammatory Bowel Disease
References Country Year IBD incidence (per 100,000) IBD prevalence (per 100,00) Other comments Kugathasan et al. [5] USA 2003 IBD 7.1 N/A Prospective CD 4.5 Population based UC 2.2 Malaty…
Gut Immunity and Inflammatory Bowel Disease
Fig. 2.1 Basic organizational structure of the follicular associated epithelium (FAE). The main functional component of the FAE is the M (microfold) cell, which is specialized in transepithelial antigen transport….
