(1) Section of Pharmacology, Department of Medicine, University of Perugia, Building D, 2nd floor, Severi Square 1, San Sisto, Perugia, I-06132, Italy Giuseppe Nocentini Email: giuseppe.nocentini@unipg.it Introduction Owing to…
Fig. 1 Molecular mechanism of glucocorticoid action. GR glucocorticoid receptor, GC glucocorticoid, HSP heat-shock protein, FKBP FK506-binding protein, NF-kB nuclear factor-kB Genetic and Epigenetic Predictors of GC Response Given the…
2. Zetterstrom R (2008) The discovery that cortisone may effectively ameliorate inflammatory and allergic disease. Acta Paediatr 97:513–517PubMedCrossRef 3. Hench PS (1938) The ameliorating effect of pregnancy on chronic atrophic…
DCI Anti-inflammatory activity Mineralocorticoid effect Dose equivalence (mg) Half-life (h) Hydrocortisone 1 1 20 8–12 Cortisone 1 0.8 25 8–12 Prednisone 4 0.8 5 12–36 Prednisolone 4 0.8 5 12–36…
Category Definition Exclusions Systemic Arthritis in one or more joints with or preceded by fever of at least 2-week duration. Signs or symptoms must have been documented daily for at…
Inhibition of growth Osteopenia–osteoporosis (impaired peak bone mass accrual in childhood and adolescence) Hypertension Fluid retention Hypokalemic alkalosis Weight gain Hyperlipidemia Diabetes mellitus Avascular necrosis of bone Nephrocalcinosis Uricosuria Poor…
Drug Potency (relative to cortisol) Salt-retaining properties Half-life Biologic half-life Oral bioavailability (%) Cortisone acetatea 0.8 Present 1.5 8–12 90 Prednisolone 5 Moderate 2 12–36 100 Methylprednisolone 4 Low 2.3…
Fig. 2.1 Common locations of pediatric bone tumors. The location of a bone tumor is frequently the first information available to narrow the differential diagnosis of a bone lesion. This…
Fig. 9.1 Pre-operative x-ray (a) and MRI (b) demonstrating an aggressive sarcoma of the proximal humerus in a 5-year-old boy. A vascularized fibula (c) was harvested and used to reconstruct…
Fig. 11.1 Teaching tools The physical and emotional care information that the family receives at the initial appointments can become very overwhelming. It’s the role of the ONN to assess…
