Basic Principles of Biopsy
Fig. 3.1 Plain radiograph of the knee demonstrating an aggressive appearing lesion in the distal femur. Note the bone destruction, osteoid formation, and periosteal reaction 3.3 Types of Biopsy After…
PEDIATRICS
Survivorship
16.2.2 National Comprehensive Cancer Network Survivorship Guidelines On January 31, 1995, this national alliance was created to develop and institute standards of care for the treatment of cancer and perform…
Novel Therapies on the Horizon
Beug ST, Tang VA, LaCasse EC, Cheung HH, Beauregard CE, Brun J, Nuyens JP, Earl N, St-Jean M, Holbrook J et al (2014) Smac mimetics and innate immune stimuli synergize…
Recurrent Bone Tumors
© Springer International Publishing Switzerland 2015Timothy P. Cripe and Nicholas D. Yeager (eds.)Malignant Pediatric Bone Tumors – Treatment & ManagementPediatric Oncology10.1007/978-3-319-18099-1_14 14. Recurrent Bone Tumors Joanne Lagmay1 and Nicholas D. Yeager2 (1) Division of Pediatric Hematology/Oncology, Shands Hospital…
Post-therapy Surveillance of Bone Tumors
Criterion WHO RECIST 1.1 Definition of measurable disease Bidimensional, no minimum lesion size Minimum size of 10 mm on anatomic imaging Method of measurement Sum of the product of diameter…
Psychosocial Effects of Pediatric Bone Tumors and Recommendations for Supportive Care
© Springer International Publishing Switzerland 2015Timothy P. Cripe and Nicholas D. Yeager (eds.)Malignant Pediatric Bone Tumors – Treatment & ManagementPediatric Oncology10.1007/978-3-319-18099-1_12 12. Psychosocial Effects of Pediatric Bone Tumors and Recommendations for Supportive Care Cynthia A. Gerhardt1 , Amii C. Steele2 ,…
Chemotherapy Regimens for Patients with Newly Diagnosed Malignant Bone Tumors
Study Years No. of patients Regimen Findings IESS-I (Nesbit et al. 1981, 1990) 1973–1978 342 VAC vs. VACD vs. VAC + Pulm XRT Patients receiving DOX experienced best outcomes Patients…
Fertility Preservation and Reproductive Health in Pediatric Bone Tumor Patients
High risk Cyclophosphamide Ifosfamide Melphalan Busulfan Intermediate risk Cisplatin with low cumulative dose Carboplatin with low cumulative dose Adriamycin Low risk Actinomycin D Vincristine Methotrexate 5.3 Female Fertility Female fertility…
Histological Response and Biological Markers
Reference Response grade Response grade definition Huvos (1988), Provisor et al. (1997) I Viable; little to no chemotherapeutic effect II Partially necrotic III Largely necrotic IV Totally necrotic; no histologic…
Signs and Symptoms
Fig. 1.1 Location of primary tumors in osteosarcoma and Ewing sarcoma (percentage) Fig. 1.2 Presenting symptoms in osteosarcoma and Ewing sarcoma (percentage) 1.3 Sex and Ethnicity There is a slight…
