The electrical discharge of neurons associated with seizure activity stimulates a marked rise in cerebral metabolic activity. Estimates from animal experiments indicate that energy utilization during seizures…
Pharmacokinetic interactions, sometimes leading to adverse clinical situations, have long been recognized as an occasionally unavoidable facet of antiepileptic drug (AED) treatment (1,2). Since the mid-1990s, there…
INTRODUCTION Infantile epileptic encephalopathies are a group of epilepsies presenting in infancy and characterized by pharmacoresistant seizures, cognitive impairment, and a spectrum of psychiatric and behavioral disorders….
In the past, almost all children with a seizure of any type, febrile or afebrile, were placed on long-term therapy with antiepileptic drugs (AEDs). This was based…
INTRODUCTION For the vast majority of people who develop epilepsy, initial therapy consists of pharmacologic treatment with one or more of the available antiseizure drugs (ASDs). These…
The unique mechanism of action of lacosamide, as well as a lack of significant drug interactions, a relatively mild adverse effect profile, and the availability of both…
Epilepsy is suspected when there is repetition of seizures or an unprovoked seizure is accompanied by a probability of further seizures similar to the general recurrence risk…
Sleep and epilepsy are interrelated; worsening of one leads to worsening of the other and a vicious cycle starts. Sleep activates interictal epileptiform discharges (IEDs) and seizures….
The first 4 weeks of life represent one of the greatest periods of seizure hazard during childhood. The occurrence of seizures within this neonatal period is associated…
For a long time, neonatal seizures and focal epilepsies in infancy have been viewed with suspicion for a probable association with brain lesions. Now, it is well…
