Improving the Preclinical Mouse Efficacy Studies of Adenomyosis
Outcome measure Animal efficacy studies Clinical trials Incidence of adenomyosis + − Number of nodules + − Depth of myometrial infiltration + − Grade of levels of cell invasiveness +…
Current Treatment for Adenomyosis
Fig. 12.1 (a) Laparoscopic view of the uterus with a posterior adenomyoma of 6 cm. (b, c) Sharp excision of the adenomyoma. Typically, a cleavage plane from healthy myometrium is…
The Role of the Myometrium in Adenomyosis
Parity Number of uteri Mean weight (SD) Maximum weight (gm) Vertical length Transverse Anteroposterior 0 30 63.2 ± 21.4 110 7.7 ± 0.2 4.7 ± 0.1 2.9 ± 0.2 1 26 90.4 ± 39.8 170 8.6 ± 0.3 5 ± 0.2 3.5 ± 0.2 2,3 173…
The Incidence and Clinical Significance of Adenomyosis
Diagnostic cut off point References >1 HPF [84] >0.5 LPF (1 mm) [89, 112, 120] >1 medium-power field (×100) [32] >1 LPF [85] >1/4 of total uterine wall thickness [37]…
Adenomyosis and Endometrial Carcinoma
5. Cullen TS. Cancer of the uterus, its pathology, symptomatology, diagnosis, and treatment. New York: D. Appleton and Co.; 1900. 6. Cullen TS. Adenomyoma of the uterus. Philadelphia/London: W. B….
The Pathophysiology of Adenomyosis
34. Robboy SJ, Taguchi O, Cunha GR. Normal development of the human female reproductive tract and alterations resulting from experimental exposure to diethylstilbestrol. Hum Pathol. 1982;13:191–8. 35. Gordts S, Brosens…
The Endometrium in Adenomyosis
2. Benagiano G, Brosens I, Habiba M. Structural and molecular features of the endomyometrium in endometriosis and adenomyosis. Hum Reprod Update. 2014;20:386–402.PubMed 3. Carvalho L, Podgaec S, Bellodi-Privato M, Falcone…
History of Adenomyosis
© Springer International Publishing Switzerland 2016Marwan Habiba and Giuseppe Benagiano (eds.)Uterine Adenomyosis10.1007/978-3-319-13012-5_1 1. History of Adenomyosis Giuseppe Benagiano1 , Ivo Brosens2 , Marwan Habiba3, 4 and Donatella Lippi5 (1) Department of Gynaecology, Obstetrics and Urology, Policinico Umberto I° of Sapienza, University…
Myometrial Cystic Adenomyosis
1. Myometrial location: Intramural, submucous, subserous 2. Uterine site: Midline, paramedian, lateral 3. Structure: Cystic, mixed solid and cystic, cyst with polypoid growth 4. Content: Clear fluid or hemorrhagic fluid…
The Animal Model of Adenomyosis
24. Brody JR, Cunha GR. Histologic, morphometric, and immunocytochemical analysis of myometrial development in rats and mice: II. Effects of DES on development. Am J Anat. 1989;186:21–42.CrossRefPubMed 25. Cunha GR….
