Role of Systemic Therapy in the Management of Uterine Sarcomas
Study Stage Number Clinical outcome Kapp et al. [8] I 951 5-year DSS: 76 % II 43 5-year DSS: 60 % III 99 5-year DSS: 45 % IV 303 5-year…
Effects of Tamoxifen and Other SERMs in the Endometrium and Follow-Up of Patients
SERM Breast Uterus Tamoxifen − ++ Raloxifene − − Toremifene − +/− Idoxifene − +/− Droloxifene − +/− GW 5638 − +/− Arzoxifene − − EM-652 − +/− Many of…
Prognostic and Predictive Factors in the Management of Carcinoma Endometrium
Stage 5 years survival (%) 1A 88 1B 75 11 69 111A 58 111B 50 111C 47 1v A 17 1v B 15 Types of the Tumor There are two…
Metabolic Syndrome and Endometrial Cancer
NCEP-ATPIII [75] Modified WHO [9] EGIR [76] AACE [77] IDF [1] Simplified definition of metabolic syndrome [78] Mandatory … Insulin resistancea >75th percentile glucose ≥110 mg/dL; 2 h glucose…
Therapeutic Strategies in Recurrent and Metastatic Endometrial Cancer
Characteristic Type I Type II Chronic estrogenic stimulation Present (hormone dependent) Absent (not hormone dependent) Growth Slow growing Rapid Precursor lesion Atypical hyperplasia Endometrial intraepithelial carcinoma Age at initial diagnosis…
Sentinel Node Evaluation in Endometrial Cancer
Fig. 15.1 Lymph node evaluation road map. SLN, sentinel lymph node; LND, lymphadenectomy Sentinel Lymph Nodes and Endometrial Cancer The first reported use of SLN mapping in endometrial cancer was…
Uterine Sarcomas: Risk Factors, Clinical Presentation, Diagnosis, and Staging
Mesenchymal tumors Mixed epithelial and mesenchymal tumors Endometrial stromal and related tumors Carcinosarcoma Endometrial stromal sarcoma, low grade Adenosarcoma Endometrial stromal nodule Carcinofibroma Undifferentiated stromal sarcoma Adenofibroma Smooth muscle tumors…
Systemic Treatment of Advanced Endometrial Carcinoma
Drug Dose Response rate (%) Cisplatin 50–100 mg/m2 every 3 weekly 18–27 Doxorubicin 50–60 mg/m2 every 3 weekly 22–32 Paclitaxel 175–250 mg/m2 every 3 weekly 36 In order to improve…
Hormone Therapy in Normal Postmenopausal Women and After Treatment for Endometrial Cancer
Estrogen-only HT increases the risk in women with uterus Continuous combined HT reduces the risk Cyclic combined HT neither offers protection nor does it increase risk Cyclic Sequential HT use…
Endometrial Cancers in Young Women: Conservative Management and Fertility Preserving Options
History of current breast cancer Liver disease (i.e., severe cirrhosis) or liver tumors (hepatocellular adenoma or hepatoma) Use of medications (i.e., phenytoin, carbamazepine, barbiturates, primidone, topiramate, oxcarbazepine, or rifampicin) Counseling…
