Epidemiology of Pediatric Inflammatory Bowel Disease
References Country Year IBD incidence (per 100,000) IBD prevalence (per 100,00) Other comments Kugathasan et al. [5] USA 2003 IBD 7.1 N/A Prospective CD 4.5 Population based UC 2.2 Malaty…
Gut Immunity and Inflammatory Bowel Disease
Fig. 2.1 Basic organizational structure of the follicular associated epithelium (FAE). The main functional component of the FAE is the M (microfold) cell, which is specialized in transepithelial antigen transport….
Puberty and Pediatric-Onset Inflammatory Bowel Disease
Hormone Stage/age Male Female Dehydroepiandrosterone sulfate (DHEAS) (μg/dL) Tanner I <89 <46 Tanner II <81 15–113 Tanner III 22–126 42–162 Tanner V 110–510 45–320 Luteinizing hormone (LH) pediatric (IU/L) 1–7…
The Natural History of Crohn Disease in Children
Fig. 7.1 Yearly Crohn disease activity over the first 10 years after diagnosis in a Danish population of children diagnosed prior to 15 years of age. Data from Langholz et…
Natural History of Indeterminate Colitis
Author Population Initial dx IC Follow-up dx UC Follow-up dx CD Other follow-up dx (IC, not IBD, probable IBD) Moum et al. [8, 29] Adult 35 12 6 17 Joossens…
Natural History of Ulcerative Colitis in Children
2. Michener WM, Farmer RG, Mortimer EA. Long-term prognosis of ulcerative colitis with onset in childhood or adolescence. J Clin Gastroenterol. 1979;1(4):301–5.PubMedCrossRef 3. Hyams JS, Davis P, Grancher K, Lerer…
Early Onset Inflammatory Bowel Disease
2. Langholz E, Munkholm P, Krasilnikoff PA, Binder V. Inflammatory bowel diseases with onset in childhood. Clinical features, morbidity, and mortality in a regional cohort. Scand J Gastroenterol. 1997;32(2):139–47.PubMedCrossRef 3….
The Gut Microbiota and IBD
3. Rath HC, et al. Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats. J Clin Invest. 1996;98(4):945–53.PubMedCrossRef 4. Sartor RB….
Cytokines and Inflammatory Bowel Disease
2. Reinecker HC, et al. Enhanced secretion of tumour necrosis factor-alpha, IL-6, and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn’s disease. Clin…
Genetics of Inflammatory Bowel Diseases
Fig. 1.1 Associations of the IL12/IL23- and IL27-regulating genes with IBD in keeping with the TH1 and TH2/TH17 theory (Wang et al. 2010). Only the main proteins in these pathways…
