Bone Health in Pediatric Inflammatory Bowel Disease
Fig. 23.1 Bone formation (+) and resorption (−) during growth. (From Baron [12]. This material is reproduced with permission of John Wiley & Sons, Inc.) Changes in Cortical and Trabecular…
Pharmacogenetics in IBD
Fig. 25.1 Frequency distribution histogram of level of RBC TPMT enzyme activity in blood samples from 298 randomly selected Caucasian blood donors Fig. 25.2 Common TPMT mutant alleles. Wild type…
Measurement of Quality of Life in Pediatric Inflammatory Bowel Disease
Fig. 45.1 Conceptual scheme of the domains and variables involved in a quality-of-life assessment. The x axis represents subjective perceptions of health, the y axis objective health status, the coordinates…
Clinical Trials (Industry Perspective)
•S upervise : all aspects of the trial are ultimately the responsible of the investigator •M aintain Records : meticulous record keeping is critically important •A dhere to the protocol…
Pouchitis After Ileal Pouch-Anal Anastomosis
Immunosuppression Bacterial overgrowth Fecal stasis Nutritional Mucosal ischemia Crohn disease, undiagnosed Severity of UC Extraintestinal manifestations, including primary sclerosing cholangitis Smoking pANCA Immune Dysregulation One of the most pursued areas…
Biologic Therapies
Anti-tumor necrosis factor Adalimumab Monoclonal antibody Crohn disease Approved phase III Ulcerative colitis Certolizumab pegol Pegylated antibody fragment Crohn disease Approved phase III Golimumab Monoclonal antibody Ulcerative colitis Phase III …
Probiotic Therapy
Participants (# treated) Trial design Probiotic (strains) Dosing (CFU/day) Trial length (weeks) Ref. 20 (10) EBRPC Blend Probiotic (Yakult™) 1 × 1010 12 [25] 102 (52) DBRDD Single strain (E….
Growth Impairment in Pediatric Inflammatory Bowel Disease
Fig. 12.1 The GH/IGF-1 axis and its role in linear growth. The hypothalamic release of growth hormone releasing hormone (GHRH) stimulates the pulsatile release of growth hormone (GH) from the…
Transition from Pediatric to Adult Care
Disease information: date of diagnosis, location, severity Findings: Laboratories, Endoscopy, Histology, Radiology results, and dates Medical therapies: dose, duration, adverse reactions, reasons for discontinuation Surgeries Adapted from Hait et al….
Legislative Advocacy
Petar Mamula, Jonathan E. Markowitz and Robert N. Baldassano (eds.)Pediatric Inflammatory Bowel Disease2nd ed. 201310.1007/978-1-4614-5061-0_52© Springer Science+Business Media New York 2013 52. Legislative Advocacy Suzanne Rosenthal1 and Crohn’s & Colitis Foundation of America (1) Crohn’s and Colitis…
