Fig. 33.1 Design of the REACH study in pediatric Crohn disease Post hoc analyses of the REACH study evaluated the effect of infliximab in children with perianal CD. Seventy percent…
Increased interleukin (IL)-10 Increased IL-2 Inhibition of neutrophil chemotaxis Decreased leukotriene B4 (LTB4) Decreased tumor necrosis factor alpha Decreased IL-6 Decreased IL-8 Decreased selective adhesion molecules (SAM) Improved understanding of…
Fig. 31.1 Azathioprine (AZA) metabolism (XO xanthine oxidase; 6-TU 6-thiouric acid; 6-TIMP 6-thioinosine monophosphate) An apparent genetic polymorphism has been observed in TPMT activity in both the Caucasian and African-American…
Budesonide n = 22 Prednisolone n = 26a p-value Moon face 5 15 0.01 Buffalo hump 0 1 NS Acne 1 7 0.033 Hirsutism 2 3 NS Skin striae…
3. Kanof ME, Lake AM, Bayless TM. Decreased height velocity in children and adolescents before the diagnosis of Crohn’s disease. Gastroenterology. 1988;95(6):1523–7.PubMed 4. Levine A, et al. Consensus and controversy…
2. Rutgeerts P, Goboes K, Peeters M, et al. Effect of faecal stream diversion on recurrence of Crohn disease in the neoterminal ileum. Lancet. 1991;338:771–4.PubMedCrossRef 3. Perencevich M, Burakoff R….
Fig. 13.1 Bone modeling and remodeling. Bone modeling occurs uniquely in children and results from the combined activities of osteoblasts, osteoclasts and the growth plate cells. Its result is bone…
Extraintestinal manifestation Prevalence Growth failure ++++ Sacroiliitis ++++ Osteoporosis/osteopenia +++ Peripheral joint inflammation +++ Aphtous lesions +++ Primary sclerosing cholangitis ++ Granulomatous skin lesion ++ Erythema nodosum ++ Pyoderma gangrenosum…
Test Findings Significance Complete blood count and differential Anemia (microcytic, macrocytic, normocytic), thrombocytosis, leukocytosis Anemia: Assess severity of blood loss, evaluate for iron and other macronutrient deficiencies. Reported prevalence 16–77%…
Laboratory test Organism suggested or identified Microscopic stool examination Fecal leukocytes Invasive or cytotoxin-producing bacteria Trophozoïtes, cysts, oocysts, or spores Giardia lamblia, Entameoba histolytica, Schistosoma mansoni Spiral or S-shapped gram-negative…
