Fig. 33.1 The translational pathway The focus on translation is due to the ever-increasing research budgets in the face of stubbornly stable global or national health indices. Research that has…
Fig. 15.1 Assessment, complementary interventions, pharmacological treatment, and effective implementation fit together like puzzle pieces for the effective management of pain in neonates Assessment of Distress and Pain in Neonates…
Provider must be qualified and credentialed Provider must have skills to rescue patient Provider must have knowledge of medications and potential complications Provider must prepare for a deeper level of…
Drug Neurotoxicity/altered plasticity Reference Propofol Yes [10, 11, 19, 26, 40, 42] Midazolam Yes [11, 18] Pentobarbital Yes [26] Chloral hydrate Yes [29, 54] Ketamine Yes [8, 11, 27, 33,…
Fig. 26.1 Phases of drug development. NDA New Drug Application, IND Investigational New Drug Application Initial studies in humans (Phase 1 trials) are the first stage of testing in human…
Brief: <10 min Intermediate: 10–20 min Extended: >20 min Adapted from Green SM, Roback MG, Miner JR, Burton JH, Krauss B. Fasting and Emergency Department Procedural Sedation and Analgesia: A…
Fig. 24.1 Staffing requirements for procedural sedation and analgesia in Australia and New Zealand. Reprinted with permission from Australian and New Zealand College of Anaesthetists. Guidelines on Sedation and/or Analgesia…
Fig. 17.1 Context-sensitive half-times [11] with permission of Oxford University Press Drugs commonly used in intensive care [12], such as morphine, midazolam, and vecuronium, all produce active metabolites that are…
Fig. 5.1 A working model of pediatric sedation. The x-axis is the time of phase of sedation. The y-axis is the depth of sedation, ranging from inadequate to oversedation. A…
94 % Opioid/benzodiazepine combination 70 % Chloral hydrate 51 % Ketamine 46 % Pentobarbital 16 % Propofol 6 % Nitrous oxide Table 13.2 Location of sedations [2] 86 % Inpatient…
