Obgyn Key

Fig. 13.1 Angiopoietin functions in the vasculature. In the adult vasculature, angiopoietin-1 (Ang1) contributes to the stabilization of pre-existing vessels by providing a basal signal that leads to constitutive Tie2…

Fig. 8.1 Summary of signal transduction pathways operating downstream of vascular endothelial growth factor-A (VEGFA) in endothelial cells of relevance for vascular permeability in vivo . See text for details….

Fig. 2.1 Arterial and venous precursor cell migration. a At 12 hpf, angioblasts are located within the anterior and posterior lateral plate mesoderm (LPM) in two bilateral stripes. Presumably, even at…

Fig. 3.1 Association of pericytes and endothelial cells. a Schematic representation of endothelial cells (blue) and mural cells (pink). Vascular smooth muscle cells cover larger vessels such as arterioles. In…

Fig. 16.1 Antihypertensive, antithrombotic, and antiatherosclerotic effects of endothelial nitric oxide synthase (eNOS). The eNOS enzyme in endothelial cells (ECs) can be activated by shear stress or agonists such as…

Fig. 7.1 Extracellular matrix (ECM) ligands and receptors. Both ECM ligands and receptors typically possess modular structure, containing domains that allow them to bind to each other as well as…

Fig. 9.1 Cytochrome P450 (CYP)-dependent metabolism of n-6 (arachidonic and linoleic acid) and n-3 (eicosapentaenoic and docosahexaenoic acid), and metabolism of the epoxides generated to the corresponding diols by the…

Junction stabilization Small GTPase Effectors Molecular function   GEF   Rap1 a Epac a (cAMP-dependent) PDZ-GEF 1 a (cAMP-independent) C3G b Stabilization of VE-cadherin at junctions Rac Tiam (Rac specific)…

Fig. 5.1 Lymphatic vessel basics. Interstitial fluid and immune cells pass through discontinuous adherens junctions on lymphatic capillaries in a unidirectional manner. One of the main markers for lymphatic capillaries…