Decisions in Childhood SeizuresShlomo Shinnar and Ruth Shinnar
In the past, almost all children with a seizure of any type, febrile or afebrile, were placed on long-term therapy with antiepileptic drugs (AEDs). This was based…
Mechanisms of Action of Currently Available Antiseizure DrugsH. Steve White, Misty D. Smith, and Karen S. Wilcox
INTRODUCTION For the vast majority of people who develop epilepsy, initial therapy consists of pharmacologic treatment with one or more of the available antiseizure drugs (ASDs). These…
L. Buck and Howard P. Goodkin
The unique mechanism of action of lacosamide, as well as a lack of significant drug interactions, a relatively mild adverse effect profile, and the availability of both…
of Seizures in the Developing BrainStéphane Auvin
Epilepsy is suspected when there is repetition of seizures or an unprovoked seizure is accompanied by a probability of further seizures similar to the general recurrence risk…
and SleepSejal V. Jain
Sleep and epilepsy are interrelated; worsening of one leads to worsening of the other and a vicious cycle starts. Sleep activates interictal epileptiform discharges (IEDs) and seizures….
SeizuresEli M. Mizrahi
The first 4 weeks of life represent one of the greatest periods of seizure hazard during childhood. The occurrence of seizures within this neonatal period is associated…
Syndromes: Familial Benign Seizures Starting in Neonates and InfantsGiuseppe Capovilla and Pasquale Striano
For a long time, neonatal seizures and focal epilepsies in infancy have been viewed with suspicion for a probable association with brain lesions. Now, it is well…
Dominant Focal EpilepsiesSarah Weckhuysen, Mary Kurian, Fabienne Picard, and Stephanie Baulac
The familial focal epilepsies with onset in childhood or adolescence are classified according to the focus of seizure onset in different members of the same family. Seizure…
T. Hsieh and Elizabeth A. Thiele
When rufinamide received its approval from the U.S. Food and Drug Administration (FDA) in November 2008, it was the first time that a new anticonvulsant medication was…
Methsuximide, and TrimethadioneSudha Kilaru Kessler
ETHOSUXIMIDE Ethosuximide (ESM) is a succinimide antiepileptic drug in clinical use since 1958 for a limited spectrum of seizure types, chiefly absence seizures, for which it remains…
