Follicular Development and Oocyte Growth
Fig. 2.1 The structures of different follicles and its development are shown in a clockwise direction proceeding from the primordial follicle to pre-ovulatory follicle as well from ovulating to corpus luteum…
Obstetric Outcome of In Vitro Maturation Treatment and Risk of Congenital Malformations
Sun-Chi et al.a Buckett et al. Fadini et al. IVM Spontaneous IVM IVF ICSI Spontaneous IVM ICSI Number of infants 19 21 31 133 104 338 153 148 Birthweight…
Natural Cycle IVF with Spontaneous LH Surge
Unsolved problems Possible solutions Advantages/drawbacks Uncontrolled LH surge Flexible scheduling Very challenging GnRH antagonists Additional cost, inefficient? Low-dose clomiphene Endometrial effect? Premature ovulation NSAIDs Cheap, efficient Empty follicle Follicular flushing…
Minimal Stimulation for IVF with Clomiphene Citrate
Fig. 14.1 Protocol for minimal stimulation and natural cycle IVF. GnRHa GnRH agonist, OR oocyte retrieval, ET embryo transfer, Cryo cryopreservation Method for Determining the Oocyte Retrieval Period After confirming follicular…
Laboratory Aspect of IVM Treatment
Fig. 25.1 Immature oocyte with compacting cumulus cells surrounding the oocyte In Vitro Maturation of Immature Oocytes The source of immature is the most critical point for oocyte maturation, but the…
Mitochondria of the Oocyte
Fig. 4.1 Human germinal vesicle (a) and metaphase I (b) oocytes. Mitochondria are absent from the cortical region of the cytoplasm in germinal vesicle oocytes while they are dispersed in the…
Development of IVM Treatment: Combination of Natural Cycle IVF with IVM
Fig. 27.1 Detailed protocol for natural cycle IVF combined with IVM treatment (Based on Lim et al. [27] with modification) In addition, it has been reported that the clinical outcomes of…
IVM as Clinical Treatment: Overview
Characteristics from 1187 pregnancies Singleton pregnancies (n = 960) Twin gestation pregnancies (n = 221) Triplet gestation pregnancies (n = 5) Quadruplet gestation pregnancies (n = 1) Mean gestational age at delivery (weeks + days) 37 + 4 36 + 5 35 + 2 29 + 0 No….
Genetic Aspect of Recurrent Implantation Failure
Gene Genotype associated with RIF Genotype associated with RM Ethnicity Other associated phenotypes Apo E Nil E2, E3, E4 [34] Asian, Caucasian Higher LDL cholesterol ACE Nil Insertion, deletion [35]…
Mild Stimulation Protocols for Oncofertility Patients
© Springer International Publishing AG 2017Ri-Cheng Chian, Geeta Nargund and Jack Y. J. Huang (eds.)Development of In Vitro Maturation for Human Oocytes10.1007/978-3-319-53454-1_18 18. Mild Stimulation Protocols for Oncofertility Patients William L. Ledger1 , Nur Atiqah Hairudin1 and Chan Soke Yee Sara1 (1) Department of…
