of Epilepsies in ChildhoodDouglas R. Nordli, Jr.
INTRODUCTION AND HISTORICAL BACKGROUND Early discussions on the classification of epilepsy have had a marked and lasting impact upon our current understanding of the disease, and might…
Rating, Nicole Wolf, Thomas Bast, and James J. Riviello, Jr.
CHEMISTRY, ANIMAL PHARMACOLOGY, AND MECHANISM OF ACTION Sulthiame (STM) is a sulfonamide derivate, N-(4-sulfamoylphenyl)-1,4-butansultam (Figure 63.1), a crystalline powder, with a molecular weight of 290 g/mol (1)….
Shinnar and Kenneth W. Sommerville
In the last few years, a new generation of antiepileptic drugs (AEDs) has been developed (1,2), with much interest in drugs that work on the gamma-aminobutyric acid…
Epilepsy in Infancy and Epilepsy With Myoclonic Atonic SeizuresChristian M. Korff and Pierre Genton
In this chapter, we review two well-individualized early-onset myoclonic epilepsies included in the category of genetic generalized epilepsies in the 2010 International League Against Epilepsy (ILAE) organization…
Oxcarbazepine, and EslicarbazepineBasanagoud Mudigoudar
INTRODUCTION Carbamazepine is one of the most frequently used antiepileptic medications, and is arguably supported by the best evidence base (1). It is highly effective for treatment…
and Pharmacologic Consequences of SeizuresShilpa D. Kadam and Michael V. Johnston
The electrical discharge of neurons associated with seizure activity stimulates a marked rise in cerebral metabolic activity. Estimates from animal experiments indicate that energy utilization during seizures…
of Drug Interactions: Implications for Treatment With Antiepileptic DrugsMindl M. Messinger and Barry E. Gidal
Pharmacokinetic interactions, sometimes leading to adverse clinical situations, have long been recognized as an occasionally unavoidable facet of antiepileptic drug (AED) treatment (1,2). Since the mid-1990s, there…
Epileptic Encephalopathies and De Novo MutationsRima Nabbout
INTRODUCTION Infantile epileptic encephalopathies are a group of epilepsies presenting in infancy and characterized by pharmacoresistant seizures, cognitive impairment, and a spectrum of psychiatric and behavioral disorders….
Decisions in Childhood SeizuresShlomo Shinnar and Ruth Shinnar
In the past, almost all children with a seizure of any type, febrile or afebrile, were placed on long-term therapy with antiepileptic drugs (AEDs). This was based…
Mechanisms of Action of Currently Available Antiseizure DrugsH. Steve White, Misty D. Smith, and Karen S. Wilcox
INTRODUCTION For the vast majority of people who develop epilepsy, initial therapy consists of pharmacologic treatment with one or more of the available antiseizure drugs (ASDs). These…
