Acute lesions Chronic lesions Thrombotic microangiopathy (TMA) Arterial fibrous intimal hyperplasia (FIH) or arterial occlusion by organized thrombi with or without recanalization Focal cortical atrophy (FCA) Tubular thyroidization APS nephropathy…
Clinical manifestation Association Level of evidence Dementia Association between LA and dementia Level II Cognitive dysfunction Association between aPL and cognitive dysfunction Level I Migraine No association between migraine and…
Criteria for obstetric APS 1. One or more unexplained deaths of a morphologically normal fetus at or beyond the 10th week of gestation, with normal fetal morphology documented by ultrasound…
Test Distinctive features Anti-PS/PT antibodies Strong correlation with LA Association with obstetric or thrombotic manifestations not definitely demonstrated Anti-DI antibodies Association with triple positivity Association with thrombosis (in few studies)…
© Springer International Publishing Switzerland 2015Pier Luigi Meroni (ed.)Antiphospholipid Antibody SyndromeRare Diseases of the Immune System10.1007/978-3-319-11044-8_1 1. Genetics and Origin of Antiphospholipid Syndrome Alessandra Soriano1, 2 , Miri Blank3 and Yehuda Shoenfeld1, 4 (1) Zabludowicz Center for Autoimmune…
© Springer International Publishing Switzerland 2015Pier Luigi Meroni (ed.)Antiphospholipid Antibody SyndromeRare Diseases of the Immune System10.1007/978-3-319-11044-8_4 4. The Pathogenic Mechanisms for Antiphospholipid Antibodies (aPL)-Mediated Pregnancy Loss Nicoletta Di Simone1 and Silvia D’Ippolito1 (1) Department of Obstetrics and…
Clinical Serology 1. Venous thrombosis 1. IgG anticardiolipin antibody (>20 GPL units) 2. Arterial thrombosis 2. Positive test for lupus anticoagulant 3. Recurrent fetal loss 3. IgM anticardiolipin antibody (>20…
421. Friends are considering adopting a “special needs” child from another country. The family has few details, but the video provided by the Bombay, India adoption agency of the 4-year-old…
(Courtesy of Susan John, MD.) a. Multiple sclerosis b. Acute disseminated encephalomyelitis (ADEM) c. Malignant astrocytoma d. Bacterial meningitis e. Neurocysticercosis 309. The examination of a child’s back is shown…
a. Mumps b. Varicella c. Rubella d. Measles e. Diphtheria 345. A 2-month-old child of an HIV-positive mother is followed in your pediatric practice. Which of the following therapies should…
