Legislative Advocacy

Sep 26, 2016 by in PEDIATRICS Comments Off on Legislative Advocacy

Petar Mamula, Jonathan E. Markowitz and Robert N. Baldassano (eds.)Pediatric Inflammatory Bowel Disease2nd ed. 201310.1007/978-1-4614-5061-0_52© Springer Science+Business Media New York 2013 52. Legislative Advocacy Suzanne Rosenthal1   and Crohn’s & Colitis Foundation of America (1) Crohn’s and Colitis…

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5-Aminosalicylate Therapy

Sep 26, 2016 by in PEDIATRICS Comments Off on 5-Aminosalicylate Therapy

Drug Formulation Delivery system Dosage form Release location Azo-bonded formulations Sulfasalazine (Azulfidine®) Azo bond of 5-ASA to sulfapyridine Broken down by colonic bacteria to release active 5-ASA moiety Tablet 500…

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Classification of Inflammatory Bowel Disease in Children

Sep 26, 2016 by in PEDIATRICS Comments Off on Classification of Inflammatory Bowel Disease in Children

Blood or serum Complete blood count Serum albumin Erythrocyte sedimentation rate C-reactive protein Serologies Anti-neutrophil cytoplasmic antibody Anti-Saccharomyces cerevisiae antibody Antibodies to outer membrane porin Antibodies to flagellin NOD2 genetics…

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Malignant Tumors Arising in Inflammatory Bowel Disease

Sep 26, 2016 by in PEDIATRICS Comments Off on Malignant Tumors Arising in Inflammatory Bowel Disease

Fig. 49.1 Timing in Molecular Alterations in Sporadic Colorectal Cancer and Colitis-Associated Colorectal Cancer (From Gastroenterology, 2004) [1] IBD-associated CRCs share several features in common with sporadic CRC. First, they…

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Immunizations in the Child with Inflammatory Bowel Disease

Sep 26, 2016 by in PEDIATRICS Comments Off on Immunizations in the Child with Inflammatory Bowel Disease

Immunization Type Route of administration Patient age at time of recommended administration Hepatitis B Inactivated Parenteral 0–1 year (3 doses) Diphtheria and tetanus toxoids and acellular pertussis Inactivated Parenteral 2–6…

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Inflammatory Bowel Disease in Pregnancy

Sep 26, 2016 by in PEDIATRICS Comments Off on Inflammatory Bowel Disease in Pregnancy

Safe to use when indicated Limited data but appear safe Contraindicated Oral, topical mesalamine Olsalazine Methotrexate Sulfasalazine Azathioprine/6MP Thalidomide Corticosteroids Biologics Diphenoxylate Total parenteral nutrition Cyclosporine  Loperamide Metronidazole Ciprofloxacin*  …

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Clinical Trials (Clinician Perspective)

Sep 26, 2016 by in PEDIATRICS Comments Off on Clinical Trials (Clinician Perspective)

Short-term Induce clinical remission Maintain clinical remission Improve patient’s quality of life Long-term Heal mucosa Decrease hospitalization/surgery and overall costs Reduce disease-related and therapy-related complications Promote growth and pubertal development…

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