Pharmacogenetics in IBD

Sep 26, 2016 by in PEDIATRICS Comments Off on Pharmacogenetics in IBD

Fig. 25.1 Frequency distribution histogram of level of RBC TPMT enzyme activity in blood samples from 298 randomly selected Caucasian blood donors Fig. 25.2 Common TPMT mutant alleles. Wild type…

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Clinical Trials (Industry Perspective)

Sep 26, 2016 by in PEDIATRICS Comments Off on Clinical Trials (Industry Perspective)

•S upervise : all aspects of the trial are ultimately the responsible of the investigator •M aintain Records : meticulous record keeping is critically important •A dhere to the protocol…

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Pouchitis After Ileal Pouch-Anal Anastomosis

Sep 26, 2016 by in PEDIATRICS Comments Off on Pouchitis After Ileal Pouch-Anal Anastomosis

Immunosuppression Bacterial overgrowth Fecal stasis Nutritional Mucosal ischemia Crohn disease, undiagnosed Severity of UC Extraintestinal manifestations, including primary sclerosing cholangitis Smoking pANCA Immune Dysregulation One of the most pursued areas…

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Biologic Therapies

Sep 26, 2016 by in PEDIATRICS Comments Off on Biologic Therapies

Anti-tumor necrosis factor Adalimumab Monoclonal antibody Crohn disease Approved phase III Ulcerative colitis  Certolizumab pegol Pegylated antibody fragment Crohn disease Approved phase III  Golimumab Monoclonal antibody Ulcerative colitis Phase III …

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Probiotic Therapy

Sep 26, 2016 by in PEDIATRICS Comments Off on Probiotic Therapy

Participants (# treated) Trial design Probiotic (strains) Dosing (CFU/day) Trial length (weeks) Ref. 20 (10) EBRPC Blend Probiotic (Yakult™) 1  ×  1010 12 [25] 102 (52) DBRDD Single strain (E….

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Transition from Pediatric to Adult Care

Sep 26, 2016 by in PEDIATRICS Comments Off on Transition from Pediatric to Adult Care

Disease information: date of diagnosis, location, severity Findings: Laboratories, Endoscopy, Histology, Radiology results, and dates Medical therapies: dose, duration, adverse reactions, reasons for discontinuation Surgeries Adapted from Hait et al….

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