Hereditary Cancers of the Endometrium: HNPCC Syndrome and Beyond
Amsterdam criteria I Three or more family members with a confirmed diagnosis of colorectal cancer, one of whom is a first-degree (parent, child, sibling) relative of the other two Two…
Adenomyosis and Ultrasound: The Role of Ultrasound and Its Impact on Understanding the Disease
Feature 2D-TVS Serosal contour of the uterus Uterus often globally enlarged Definition of lesion Ill-defined in diffuse adenomyosis (adenomyoma may be well-defined) Symmetry of uterine walls Anterior-posterior myometrial asymmetry…
The Myometrium in Heath and Disease
Fig. 4.1 The mouse uterus shows distinct endometrial (E), inner circular (IC) and outer longitudinal (OL) myometria layers that are separated by a loosely packed vascular layer (V) (haematoxylin and…
Improving the Preclinical Mouse Efficacy Studies of Adenomyosis
Outcome measure Animal efficacy studies Clinical trials Incidence of adenomyosis + − Number of nodules + − Depth of myometrial infiltration + − Grade of levels of cell invasiveness +…
Current Treatment for Adenomyosis
Fig. 12.1 (a) Laparoscopic view of the uterus with a posterior adenomyoma of 6 cm. (b, c) Sharp excision of the adenomyoma. Typically, a cleavage plane from healthy myometrium is…
The Role of the Myometrium in Adenomyosis
Parity Number of uteri Mean weight (SD) Maximum weight (gm) Vertical length Transverse Anteroposterior 0 30 63.2 ± 21.4 110 7.7 ± 0.2 4.7 ± 0.1 2.9 ± 0.2 1 26 90.4 ± 39.8 170 8.6 ± 0.3 5 ± 0.2 3.5 ± 0.2 2,3 173…
The Incidence and Clinical Significance of Adenomyosis
Diagnostic cut off point References >1 HPF [84] >0.5 LPF (1 mm) [89, 112, 120] >1 medium-power field (×100) [32] >1 LPF [85] >1/4 of total uterine wall thickness [37]…
Adenomyosis and Endometrial Carcinoma
5. Cullen TS. Cancer of the uterus, its pathology, symptomatology, diagnosis, and treatment. New York: D. Appleton and Co.; 1900. 6. Cullen TS. Adenomyoma of the uterus. Philadelphia/London: W. B….
The Pathophysiology of Adenomyosis
34. Robboy SJ, Taguchi O, Cunha GR. Normal development of the human female reproductive tract and alterations resulting from experimental exposure to diethylstilbestrol. Hum Pathol. 1982;13:191–8. 35. Gordts S, Brosens…
The Endometrium in Adenomyosis
2. Benagiano G, Brosens I, Habiba M. Structural and molecular features of the endomyometrium in endometriosis and adenomyosis. Hum Reprod Update. 2014;20:386–402.PubMed 3. Carvalho L, Podgaec S, Bellodi-Privato M, Falcone…
