GYNECOLOGY

The Clinical Spectrum of Preeclampsia

Sep 20, 2018 by in GYNECOLOGY Comments Off on The Clinical Spectrum of Preeclampsia

Keywords preeclampsia, eclampsia, HELLP syndrome, differential diagnosis   Editors’ comment: The fourth edition of Chesley’s Hypertensive Disorders of Pregnancy is a revision of the previous two multi-authored editions. The fact…

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Metabolic Syndrome and Preeclampsia

Sep 20, 2018 by in GYNECOLOGY Comments Off on Metabolic Syndrome and Preeclampsia

Keywords preeclampsia, pregnancy, obesity, insulin resistance, inflammation, endothelium   Editors’ comment: In the early part of the previous century the association between hypertension, increased blood sugar levels and obesity had…

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The Placenta in Normal Pregnancy and Preeclampsia

Sep 20, 2018 by in GYNECOLOGY Comments Off on The Placenta in Normal Pregnancy and Preeclampsia

Keywords placentation, preeclampsia, cytotrophoblast, antiangiogenic factors, adhesion molecules   Editors’ comment: Without the placenta we would not have preeclampsia (or human civilization either). Thus the recent explosion of research regarding…

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Angiogenesis and Preeclampsia

Sep 20, 2018 by in GYNECOLOGY Comments Off on Angiogenesis and Preeclampsia

Keywords angiogenesis, pseudovasculogenesis, soluble fms-like tyrosine kinase-1, soluble endoglin, vascular endothelial growth factor, transforming growth factor beta, placental growth factor, glomerular endotheliosis   Editors’ comment: When Chesley wrote his original…

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Endothelial Cell Dysfunction

Sep 20, 2018 by in GYNECOLOGY Comments Off on Endothelial Cell Dysfunction

Keywords endothelial cell activation, placental microvesicles, cytokines, antiangiogenic factors, eicosanoids, reactive oxygen species, lipid peroxidation   Editors’ comment: It was not until the early 1980s that physicians and scientists gained…

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Immunology of Normal Pregnancy and Preeclampsia

Sep 20, 2018 by in GYNECOLOGY Comments Off on Immunology of Normal Pregnancy and Preeclampsia

Keywords immunology, innate immune system, T regulatory cells, NK-cells, acute-phase response, trophoblast, HLA, immunoregulation, preeclampsia   Editors’ comment: Chesley in his single-authored first edition wrote little regarding immunology and preeclampsia,…

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Genetic Factors in the Etiology of Preeclampsia/Eclampsia

Sep 20, 2018 by in GYNECOLOGY Comments Off on Genetic Factors in the Etiology of Preeclampsia/Eclampsia

Keywords preeclampsia, genetics, polymorphism, linkage analysis, candidate gene, genomics, polygenic, DNA sequencing   Editors’ comment: Recognition that preeclampsia might have a genetic predeliction dates back to late 1800s reports of…

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Epidemiology of Pregnancy-Related Hypertension

Sep 20, 2018 by in GYNECOLOGY Comments Off on Epidemiology of Pregnancy-Related Hypertension

Keywords preeclampsia, epidemiology, incidence, recurrence, risk factors, cardiovascular disease, placenta   Editors’ comment: The epidemiology literature relating to hypertension in pregnancy grew substantially since the third edition, much of it…

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Introduction, History, Controversies, and Definitions

Sep 20, 2018 by in GYNECOLOGY Comments Off on Introduction, History, Controversies, and Definitions

Keywords introduction, history of preeclampsia, classification schema   Leon Chesley’s Hypertensive Disorders in Pregnancy was initially published in 1978. Then, as now, hypertension complicating pregnancy was a major cause of…

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