Cardiometabolic risk in women with PCOS
Introduction It is well known that in young women with PCOS, the cardiovascular (CV) risk is increased . In fact, in these patients, all CV risk factors including atherogenic dyslipidemia,…
Polycystic ovary syndrome and nonalcoholic fatty liver disease
Overview of metabolic risk profile and complications of NAFLD Excessive hepatic fat accumulation defines the primary event in the continuum of nonalcoholic fatty liver disease (NAFLD) that has become the…
Inositols and other supplements in the management of PCOS
Introduction Polycystic ovary syndrome (PCOS) is associated with neuroendocrine dysfunctions, insulin resistance (IR), impaired ovarian steroidogenesis and hyperandrogenism . Although the etiology of PCOS is still poorly known, androgens and…
Targeting infertility in PCOS: Unfolding “Ariadne’s thread”
Introduction The myth of Ariadne’s thread is a fitting analogy for providing a practical and logical algorithm for the management of anovulatory PCOS. The legend tells of King Minos who,…
Targeting metabolism in the management of PCOS: Metformin and beyond
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among reproductive-aged women characterized by clinical or biochemical hyperandrogenism, oligo-anovulation, and polycystic ovarian morphology. Women with PCOS have increased risk…
Combined oral contraceptives: Why, when, where?
Introduction Polycystic ovary syndrome (PCOS), a multifactorial disorder, involves mainly reproductive but also other endocrine systems. Based on the current Rotterdam criteria, the prevalence of PCOS varies between 5% and…
Intrinsic abnormalities of adipose tissue and adipose tissue dysfunction in PCOS
Funding sources This work was supported by the Brazilian National Institute of Hormones and Women’s Health/Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq INCT grant number 465482/2014-7) and Fundação de…
Diet and exercise in the management of PCOS: Starting from the basics
Obesity, insulin resistance and metabolic syndrome in PCOS Overweight and obesity constitute a modern global pandemic, with rapidly growing rates both in developed and in developing areas of the world….
The multifarious role of insulin in PCOS: From pathophysiology to therapeutic management
Funding This work was supported by academic grants to Paolo Moghetti from the University of Verona. Conflicts of interest/competing interests The author has nothing to disclose. Introduction Polycystic ovary syndrome…
The pathogenic role of androgen excess in PCOS
Introduction Polycystic ovary syndrome (PCOS) is a very common and rather complex endocrine disorder with significant reproductive and metabolic impact . The overproduction of androgens seems to have a role…
