Supportive Care
High level of emetic risk (>90 % frequency of emesis in absence of prophylaxis) Altretamine Dactinomycin Carboplatin Mechlorethamine Carmustine >250 mg/m2 Methotrexate ≥12 g/m2 Cisplatin Procarbazine (oral) Cyclophosphamide ≥1 g/m2…
High-Dose Chemotherapy/Stem Cell Transplantation (HDSCT)
© Springer Science+Business Media New York 2015Katrin Scheinemann and Eric Bouffet (eds.)Pediatric Neuro-oncology10.1007/978-1-4939-1541-5_21 21. High-Dose Chemotherapy/Stem Cell Transplantation (HDSCT) Victor Anthony Lewis1 and Shahrad Rod Rassekh2 (1) Department of Pediatrics, Alberta Children’s Hospital, Calgary, AB, Canada (2) Division of…
Targeted Therapies in Paediatric Brain Tumours
Study type Drug BSG Ependymoma Medulloblastoma/sPNET HGG LGG Other Total Outcome References Phase I Gefitinib 3 (2 SD) 1 4 2 SD [30] Phase I Lonafarnib 7 9 8 18 …
Chemotherapy
Drug Mechanism of action Common toxicities Less common toxicities Dose ranges Penetration of blood–brain barrier Intravenous Vincristine Vinca alkaloid Constipation, diarrhea, peripheral neuropathy SIADH, paralytic ileus, seizures, severe jaw pain…
Atypical Teratoid Rhabdoid Tumors
Fig. 15.1 Sagittal T1 + gadolinium and coronal T1 + gadolinium sequences of a left large parietal ATRT Pathology As described in Chap. 6, the consistent histologic feature of ATRT…
High-Grade Glioma
Fig. 10.1 (a–c) A 12-year-old female with GBM. (a) Axial T1, (b) axial T1 with gadolinium, (c) axial T2. (d–f) A 15-year-old male with malignant glioma. (d) Axial T1, (e)…
Cancer Predisposition in Children with Brain Tumors
Fig. 8.1 Bilateral acoustic neuroma in NF2 Patients with NF2 can also develop intracranial, spinal, and optic nerve sheath meningiomas, ependymomas, and gliomas of the CNS. Most meningiomas of the…
Basic Science of Pediatric Brain Tumors
Fig. 7.1 Summary of molecular subgroups and recurrent genomic alterations identified in pediatric brain tumors Integrated genomic studies have revealed that MB comprises at least four molecular variants, which are…
Epidemiology of Central Nervous System Tumors
© Springer Science+Business Media New York 2015Katrin Scheinemann and Eric Bouffet (eds.)Pediatric Neuro-oncology10.1007/978-1-4939-1541-5_3 3. Epidemiology of Central Nervous System Tumors Daniel L. Keene1 and Donna L. Johnston2 (1) Department of Pediatrics, Children’s Hospital of Eastern Ontario, Ottawa, ON, Canada…
Introduction
Neurooncology (chair) Case managers/nurses Neurosurgery (chair) Social work Neuroradiology Physiotherapy Neuropathology Occupational therapy Radiation oncology (chair) Dietician Neuroophthalmology
