29 Therapeutic Abortion Melody Y. Hou Therapeutic abortion is defined as the intended interruption of an established pregnancy. Under the landmark 1973 Roe vs. Wade decision, the United States Supreme Court ruled that abortion is a legal procedure up until the point when the fetus becomes viable, or “has the capability of meaningful life outside the mother’s womb.” Although individual States may regulate or prohibit abortion after viability, these actions are not permitted if abortion is deemed medically necessary to preserve the life or health of the woman seeking abortion. Prior to viability, States may enact restrictions if they do not create “undue burden” on the woman. Abortion is an important issue in reproductive health, historically and worldwide, and few other topics in medicine have attracted as much debate. Some people feel that therapeutic abortion should be illegal because it destroys a developing human life. However, history has shown that a woman who has an undesired pregnancy will seek abortion despite the legal or social restrictions in her society, and that maternal mortality rate decreases significantly whenever and wherever abortion is safe and legal. Abortion has been described as early as 2737 Bc, and found in civilizations as diverse as the Chinese, Greek and Roman Empires. With the rise of Christianity, abortion and contraception became more controversial, culminating in the criminalization of abortion throughout the United States by the 1870s. Over the next century, thousands of women died or sufered serious injuries due to “back alley” abortions, and caring for women sick or dying from sepsis caused by these illegal and unregulated procedures became a common experience for medical trainees. By 1970, the American Medication Association (AMA), which had originally supported the criminaliza-tion of abortion in order to establish physician dominance over nonphysician clinicians, reversed its stance on abortion and called for its legalization. Three years later, the US Supreme Court recognized the need for safe and legal abortion with its landmark decision in Roe vs. Wade. Since then, there has been an opposing movement in the United States to repeal or limit the abortion rights granted by this decision. Unintended pregnancy and abortion are important public health issues worldwide. The majority of the world’s population lives in countries where abortion is restricted or generally prohibited. In 2008, 26% of all people resided in countries where abortion was permitted only to save a woman’s life or is prohibited altogether, whereas 35% lived in countries where abortion was permitted only to preserve either physical or mental health or for socioeco-nomic grounds. The remaining 39% resided in countries where there were no restrictions as to reason for the procedure. Wherever she lives, a woman’s likelihood of having an abortion is the same, whether abortion be considered legal or illegal. In countries where abortion is legal and accessible, abortions are safe and complications are rare. In countries where abortion is restricted, abortions are unsafe, performed by persons lacking in necessary skills or in an environment that does not meet minimal medical standards, or both. Methods of unsafe abortion that are practiced include drinking bleach or turpentine, inserting foreign objects such as coat hangers or sticks into the uterus, or jumping of stairs or roofs. One in four women undergoing unsafe abortion will face serious complications. Complications from unsafe abortions account for 13% of maternal mortality worldwide. In the United States, nearly half of all pregnancies are unintended. Four in 10 of these unintended pregnancies end in abortion, accounting for 22% of all pregnancies, excluding miscarriage. Half of all American women have had an unintended pregnancy, and 35% are estimated to have had an abortion before age 35 years. It is important not to assume that a positive pregnancy test is good news for a patient. Any woman who tests positive for an unplanned pregnancy should be counseled on all options, including abortion, adoption, or parenting the resulting child. The information must be handled sensitively and empathetically, since this decision is personal and may be extremely difficult for a patient. Efforts should be made to ensure that the patient’s choice is not coerced. As abortion laws vary from State to State, these restrictions, such as 24-hour waiting periods, spousal notification, and mandatory ultrasound-viewing, must also be considered during counseling. If the patient elects termination, she must be informed regarding the nature of the procedure and its risks. Legal abortion in the United States is among the safest of medical procedures, with less than 0.3% of abortion patients experiencing a complication requiring hospitalization. Abortion risk increases with gestational age. Based on the most recently published national review of mortality risk from 1988 to1997, mortality risk was determined to be 0.1 per 100 000 abortions done at or before 8 weeks, 3.4 in 100 000 between 16 weeks and 20 weeks, and 8.9 in 100 000 at 21 weeks or more. However, timely access to abortion services may be difficult since 87% of counties in the United States have no abortion providers, and 35% of American women live in those counties. Access to abortion services becomes more difficult with increasing ges-tational age, since there is a shortage of providers trained to do abortions in later gestations. A careful history should be taken, which includes documenting the patient’s last menstrual period (LMP) and any pregnancy symptoms she may be experiencing. (In this chapter, all gestational ages will refer to menstrual weeks, with the woman’s LMP as the reference point.) If the pregnancy has not been confirmed, a urine pregnancy test should be done. On physical exam, assess the size of the uterus and its position (ante- or retroverted, ante- or retrofexed), as well as any tenderness or masses in the adnexa. A preprocedure ultrasound will confirm the ges-tational age and help exclude the presence of an ectopic pregnancy or any pathology that may complicate the procedure, such as fibroids, müllerian duct anomalies, or a multiple pregnancy. Since abortions carry a 5% risk of rhesus (Rh) D alloimmunization in susceptible patients, Rh antigen status should also be determined and Rh negative patients treated with D immunoglobulin. Most procedures are performed under local anesthesia, such as a paracervical block, but this may not be completely effective. Local anesthesia may be augmented with sedation for patient comfort, particularly in later gestational ages. Prophylactic antibiotics are also recommended since a meta-analysis showed that antibiotics reduced the rate of postoperative endometritis by half, including women in low-risk groups. The most common method for first trimester abortion, or abortions performed prior to 13 weeks, is via vacuum aspiration (also known as suction curettage) (Fig 29.1). Vacuum aspiration consists of dilating the cervix and inserting a suction cannula that is connected to a vacuum source. Adequate cervical dilatation is achieved through use of serial tapered rods of increasing diameters, known as dilators. The vacuum source can either be from an electric pump or created using a modifed 60 cc syringe, known as manual aspiration. Under adequate vacuum, the cannula is rotated to clear the uterus of the products of conception. Another surgical method is dilation and curettage (D&C), in which the cervix is dilated until a curette or forceps of adequate size can be inserted to remove the products. After the procedure, the specimen obtained should be examined immediately to confirm products of conception and the completion of the abortion. If no products of conception are identified, a review of a preprocedure and postprocedure ultrasound and serial beta human chorionic gonadotropin (β-HCG) levels can allow for early diagnosis of an unruptured ecto-pic pregnancy. In very early gestations (less than 6 weeks) aspiration can miss the pregnancy. The tissue may also be difficult to identify in the specimen or on ultrasound after the procedure. However, careful aspiration can still be attempted with appropiate follow-up. Prior to 49–63 days of gestation, medical abortion may also be offered (Table 29.1, Evidence Box 29.1). Mifepris-tone is an oral antiprogestin that binds to the progesterone receptor at a greater infinity than progesterone. By blocking progesterone, it alters the lining of the uterus and disrupts the attachment of the embryo. Mifepristone may be administered in combination with misoprostol (a prostaglandin) to induce expulsion of the products of conception. Rather than the single surgical event that occurs with vacuum aspiration, a woman who chooses medical abortion experiences the process as a series of events: taking the medication, feeling symptoms, and experiencing the expulsion. From initiation to completion, medical abortion takes more time than surgical, and involves more observed blood loss. However, women may elect medical abortion because of concerns for the risks of surgical abortion or preferences for privacy and control. Women will experience moderate-to-heavy bleeding and cramping with the expulsion, which may be accompanied by nausea, vomiting, and diarrhea depending on the medication regimen. Eighty-five percent of women will abort within 3 days of misoprostol administration, although for a few patients the process may take up to a few weeks. Completion is most often confirmed by transvaginal ultrasound, although confirmation by clinical exam is also permitted by the US Food and Drug Administration (FDA).
Definition
History and Legality
Epidemiology
Counseling
Patient History, Physical and Laboratory Tests
Methods for First Trimester Abortion
Medical abortion | Surgical abortion |