© Springer International Publishing Switzerland 2015Timothy P. Cripe and Nicholas D. Yeager (eds.)Malignant Pediatric Bone Tumors – Treatment & ManagementPediatric Oncology10.1007/978-3-319-18099-1_12 12. Psychosocial Effects of Pediatric Bone Tumors and Recommendations for Supportive Care Cynthia A. Gerhardt1 , Amii C. Steele2 ,…
Study Years No. of patients Regimen Findings IESS-I (Nesbit et al. 1981, 1990) 1973–1978 342 VAC vs. VACD vs. VAC + Pulm XRT Patients receiving DOX experienced best outcomes Patients…
High risk Cyclophosphamide Ifosfamide Melphalan Busulfan Intermediate risk Cisplatin with low cumulative dose Carboplatin with low cumulative dose Adriamycin Low risk Actinomycin D Vincristine Methotrexate 5.3 Female Fertility Female fertility…
Reference Response grade Response grade definition Huvos (1988), Provisor et al. (1997) I Viable; little to no chemotherapeutic effect II Partially necrotic III Largely necrotic IV Totally necrotic; no histologic…
Fig. 1.1 Location of primary tumors in osteosarcoma and Ewing sarcoma (percentage) Fig. 1.2 Presenting symptoms in osteosarcoma and Ewing sarcoma (percentage) 1.3 Sex and Ethnicity There is a slight…
Group Era n Dose (Gy) 5-year overall LC (%) LC with RT alone IESS-I 1973–1978 331 45–65 85 IESS-II 1978–1982 214 50–55 90 SJCRH 1978–1988 43 30–60 68 58 CESS-81…
