Fibroblast Growth Factor Signaling in Vascular Development
Fig. 4.1 Fibroblast growth factor receptor 1 (FGFR1) signal transduction. The binding of FGF-1, -2, or -4 at the interface of the IgII and IgIII domains, together with the binding…
More than a Scaffold: Extracellular Matrix in Vascular Signaling
Fig. 7.1 Extracellular matrix (ECM) ligands and receptors. Both ECM ligands and receptors typically possess modular structure, containing domains that allow them to bind to each other as well as…
Cytochrome P450-Derived Lipid Mediators and Vascular Responses
Fig. 9.1 Cytochrome P450 (CYP)-dependent metabolism of n-6 (arachidonic and linoleic acid) and n-3 (eicosapentaenoic and docosahexaenoic acid), and metabolism of the epoxides generated to the corresponding diols by the…
Junctional Signaling in Endothelial Cells
Junction stabilization Small GTPase Effectors Molecular function GEF Rap1 a Epac a (cAMP-dependent) PDZ-GEF 1 a (cAMP-independent) C3G b Stabilization of VE-cadherin at junctions Rac Tiam (Rac specific)…
Development and Differentiation of the Lymphatic Vascular System
Fig. 5.1 Lymphatic vessel basics. Interstitial fluid and immune cells pass through discontinuous adherens junctions on lymphatic capillaries in a unidirectional manner. One of the main markers for lymphatic capillaries…
