Sexually Transmitted Diseases



Sexually Transmitted Diseases


Lisa K. Tuchman

Amy L. Weiss



INTRODUCTION

Among all age groups, adolescents and young adults are at the highest risk of being diagnosed with a sexually transmitted disease (STD) due to a combination of factors, including risk-taking behaviors, increased biologic susceptibility, and barriers to accessing appropriate reproductive health care services. Although young people between the ages of 15 and 24 years comprise a quarter of the sexually experienced population, they account for up to a half of newly acquired STDs. In 2009, women aged 15 to 19 years had the highest rates of Chlamydia, gonorrhea, and HPV infection compared to all other age groups.

While often asymptomatic, the clinical presentation of most STDs in adolescents can be highly variable. Females may present with vaginal discharge, abnormal vaginal bleeding, vaginal itching, dysuria, or pain (lower abdominal, right upper quadrant, or rectal). Males may present with urethral discharge, dysuria, testicular pain or swelling, or rectal pain. Presentation can also include rash, pharyngitis, arthralgia or arthritis, and inguinal adenopathy.

Clinicians should educate adolescents about the transmission of STDs and the importance of protecting oneself. Primary prevention includes helping guide the development of healthy sexual behaviors and providing accurate sexual and reproductive health information, as well as access to reproductive health resources. Providers should remember that adolescents with chronic conditions engage in intimate relationships like their healthy peers and are also at risk for acquiring STDs. Adolescents across the United States, with limited exceptions, can consent to the confidential diagnosis and treatment of STDs, and medical care for STDs can be provided to adolescents without parental consent or knowledge. Providers should inform adolescents of their right to confidentiality and should comply with state laws and policies to ensure the confidentiality of STD-related services for adolescents.

Appropriate treatment of both the patient and the partner is essential.


DIFFERENTIAL DIAGNOSIS LIST


Bacterial Infection



  • Chancroid (Haemophilus ducreyi)


  • Gonorrhea (Neisseria gonorrhoeae)


  • Granuloma inguinale (Calymmatobacterium granulomatis)


  • Lymphogranuloma venereum (Chlamydia trachomatis)


  • Shigella species


  • Syphilis or condyloma latum (Treponema pallidum)



  • Ureaplasma urealyticum


  • Bacterial vaginosis (Gardnerella vaginalis)


Parasitic Infection



  • Pubic lice (Phthirus pubis)


  • Scabies (Sarcoptes scabiei)


Protozoal Infection



  • Trichomonas vaginalis


  • Entamoeba histolytica


  • Giardiasis (Giardia lamblia)


Viral Infection



  • Cytomegalovirus infection


  • Hepatitis A, B, or C


  • Herpes simplex virus (HSV) infection


  • HIV


  • HPV (genital warts, condyloma acuminatum)


  • Molluscum contagiosum


DIFFERENTIAL DIAGNOSIS DISCUSSION


Selected Diseases That Cause Genital Lesions


Syphilis


Etiology

Syphilis is caused by the spirochete T. pallidum.


Clinical Features



  • Primary syphilis is characterized by a painless ulcer or chancre at the site of inoculation.


  • Among children and adolescents, secondary syphilis is most common, typically presenting with a maculopapular rash involving the palms and soles. Other symptoms include mucocutaneous lesions (condyloma lata) and systemic symptoms (e.g., adenopathy, fever, pharyngitis, malaise).


  • Tertiary syphilis includes aortitis, neurologic dysfunction, and gummatous lesions of the bone, kidney, and liver.


  • Latent syphilis describes disease in patients who have no symptoms of infection. Early latent syphilis refers to infection within the past year. Late latent syphilis and syphilis of unknown duration make up the remainder of this category.


  • Men who have sex with men (MSM) accounted for 62% of all primary and secondary syphilis cases in the United States in 2009. Rates of coinfection of syphilis and HIV in MSM varied across the United States in 2009, with a median of 44.4% (30%-74%).


Evaluation

The diagnosis of syphilis is generally made by using a nonspecific (nontreponemal) antibody test such as the venereal disease research laboratory (VDRL) test and the rapid plasma reagent test. The specific tests for treponemal antibody, fluorescent treponemal antibody, absorbed (FTA-ABS), or the T. pallidum particle agglutination (TP-PA) test, remain positive for life; therefore, they do not denote activity. Nontreponemal tests can be quantified by testing serial dilutions of serum. Quantification is important because the appearance of clinical lesions correlates with a rise in titers. These titers diminish with appropriate treatment and can be used to follow response to therapy.





  • T. pallidum cannot be cultured in artificial media but darkfield examination and direct fluorescent antibody tests of lesion exudate or tissue are definitive ways to diagnose syphilis.



Herpes Genitalis


Etiology

Most recurrent cases of herpes genitalis result from herpes simplex virus-type 2 (HSV-2), although up to 50% of primary cases of genital herpes are caused by HSV-1, the type more commonly associated with stomatitis. These viruses account for up to 90% of all ulcerative lesions of the genitalia and are highly contagious; as many as 90% of women exposed to infected men develop genital herpes. Transmission can occur in patients who are asymptomatic and often unaware that they are infected, but are still shedding virus and therefore contagious.


Clinical Features

Primary infection is characterized by single or multiple vesicles that may appear anywhere on the genitalia. These vesicles spontaneously rupture to form shallow ulcers, which are exquisitely painful but resolve spontaneously without scarring. Some cases of primary genital herpes are severe enough to require hospitalization. Mild to severe systemic symptoms may accompany the genital lesions. The mean duration of the initial episode of HSV is 12 days.

Recurrent infections, which occur in some patients, are less painful and of shorter duration, lasting 4 to 5 days.


Evaluation

Viral culture allows detection of the virus in 1 to 3 days. New vesicles are unroofed and scraped for inoculation of viral media. The yield of culture diminishes over time. Direct fluorescent antibody tests are available and are rapid and highly sensitive. Serologic testing is available but is of limited value in the management of the patient.

Sep 14, 2016 | Posted by in PEDIATRICS | Comments Off on Sexually Transmitted Diseases

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