Implementation of the use of antenatal corticosteroids in the late preterm birth period in women at risk for preterm delivery




SMFM recommendations




  • 1.

    In women with a singleton pregnancy between 34 weeks 0 days and 36 weeks 6 days of gestation who are at high risk for preterm birth within the next 7 days (but before 37 weeks of gestation), we recommend treatment with betamethasone (2 doses of 12 mg intramuscularly 24 hours apart).


  • 2.

    In women with preterm labor symptoms in the late preterm period, we recommend waiting for evidence of preterm labor, such as a cervical dilatation of at least 3 cm or effacement of at least 75%, before treatment with betamethasone.


  • 3.

    In women with late preterm pregnancies receiving betamethasone, we recommend against the use of tocolysis in an attempt to delay delivery to complete the steroid course because it is unclear whether the benefits of betamethasone administration are outweighed by the risks of attempts to delay delivery.


  • 4.

    In women with late preterm pregnancies with a potential medical indication for delivery, we recommend betamethasone not be given unless there is a definitive plan for late preterm delivery.


  • 5.

    We recommend that institutions utilize standard guidelines for the assessment and management of neonatal hypoglycemia in late preterm newborns.


  • 6.

    We recommend against implementation of the Antenatal Late Preterm Steroids protocol for conditions not studied in the randomized controlled trial unless performed as part of research or quality improvement.



All authors and Committee members have filed a conflict of interest disclosure delineating personal, professional, and/or business interests that might be perceived as a real or potential conflict of interest in relation to this publication. Any conflicts have been resolved through a process approved by the Executive Board. The Society for Maternal-Fetal Medicine has neither solicited nor accepted any commercial involvement in the development of the content of this publication.


This document has undergone an internal peer review through a multi-level committee process within the Society for Maternal Fetal Medicine (SMFM). This review involves critique and feedback from the SMFM Publications and Risk Management Committees and final approval by the SMFM Executive Committee. SMFM accepts sole responsibility for document content. SMFM publications do not undergo editorial and peer review by the American Journal of Obstetrics & Gynecology. The SMFM Publications Committee reviews publications every 18-24 months and issues updates as needed. Further details regarding SMFM Publications can be found at www.smfm.org/publications . All questions or comments regarding the document should be referred to the SMFM Publications committee at pubs@smfm.org .


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May 2, 2017 | Posted by in GYNECOLOGY | Comments Off on Implementation of the use of antenatal corticosteroids in the late preterm birth period in women at risk for preterm delivery

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