Objectives
Chlamydia trachomatis (Ct)-associated pelvic inflammatory disease (PID) is a major source of morbidity and infertility. The influence of intrauterine devices (IUD) on the pathogenesis of PID is unknown. The goal of this project was to evaluate the effects of a levonorgestrel (LNG) IUD on Ct-infection.
Methods
A prospective, randomized, dual-arm, controlled trial was conducted in 18 baboons (Papio anubis). Animals with and without the IUD were inoculated using multiple cervical inoculations with 10e7 IFU/ml of human serovar E, Ct, at weeks 0,1,2,3,4. The IUD group (n=8) was followed for 40 weeks (24 wks post-insertion and 16 wks infectious phase). The no-IUD group (n=10) was followed for 16 wks. Two uninfected control animals were present in each group. Post-infection evaluation consisted of weekly cervicovaginal examinations as well as laparoscopy at weeks 0,1,2,3,4,8, and 16, and necropsy and histology at week 16.
Methods
A prospective, randomized, dual-arm, controlled trial was conducted in 18 baboons (Papio anubis). Animals with and without the IUD were inoculated using multiple cervical inoculations with 10e7 IFU/ml of human serovar E, Ct, at weeks 0,1,2,3,4. The IUD group (n=8) was followed for 40 weeks (24 wks post-insertion and 16 wks infectious phase). The no-IUD group (n=10) was followed for 16 wks. Two uninfected control animals were present in each group. Post-infection evaluation consisted of weekly cervicovaginal examinations as well as laparoscopy at weeks 0,1,2,3,4,8, and 16, and necropsy and histology at week 16.
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