Objectives
Cigarette smoking has been shown to have a dose-dependent relationship with risk of bacterial vaginosis (BV). BV is associated with a dysbiotic vaginal microbiota that is depauperate for protective Lactobacillus spp. As the mechanism linking smoking to BV is unclear, we sought to compare the vaginal metabolomes of smokers and non-smokers (17 smokers/19 non-smokers).
Methods
Metabolomic profiles were determined by gas and liquid chromatography mass spectrometry. Analysis of the vaginal microbiota by 16S rRNA gene sequencing revealed samples clustered into the three most common community state types (CSTs) – CST-I (L. crispatus-dominated), CST-III (L. iners-dominated) or CST-IV (low-Lactobacillus).
Methods
Metabolomic profiles were determined by gas and liquid chromatography mass spectrometry. Analysis of the vaginal microbiota by 16S rRNA gene sequencing revealed samples clustered into the three most common community state types (CSTs) – CST-I (L. crispatus-dominated), CST-III (L. iners-dominated) or CST-IV (low-Lactobacillus).
Stay updated, free articles. Join our Telegram channel
Full access? Get Clinical Tree
