14: Susceptibility of bacterial vaginosis (BV)-associated bacteria to secnidazole, metronidazole, tinidazole and clindamycin




Objectives


Secnidazole, a 5-nitroimidazole with a longer half-life, is structurally related to metronidazole and tinidazole. For treatment of bacterial vaginosis (BV), secnidazole is a suitable single-dose oral drug having a longer serum half-life than metronidazole. The objective of this study was to evaluate the antimicrobial susceptibility of vaginal isolates of facultative and anaerobic bacteria to secnidazole, metronidazole, tinidazole and clindamycin.




Methods


A total of 604 unique BV-related bacteria and 108 isolates of lactobacilli recovered from the human vagina of US women during the years 2009-2015 were tested for antimicrobial susceptibility by the agar dilution CLSI reference method to determine the minimal inhibitory concentration (MIC).




Methods


A total of 604 unique BV-related bacteria and 108 isolates of lactobacilli recovered from the human vagina of US women during the years 2009-2015 were tested for antimicrobial susceptibility by the agar dilution CLSI reference method to determine the minimal inhibitory concentration (MIC).

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May 2, 2017 | Posted by in GYNECOLOGY | Comments Off on 14: Susceptibility of bacterial vaginosis (BV)-associated bacteria to secnidazole, metronidazole, tinidazole and clindamycin

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