Objectives
Low dose aspirin (ASA) is recommended to prevent preeclampsia (PEC) in at-risk patients. Low dose ASA is known to cause decreased leukocyte adhesion and prostaglandin inhibition. The effects of decreased leukocyte adhesion and prostaglandin inhibition on rates of chorioamnionitis (chorio) is unknown. We hypothesize that ASA-induced decreased leukocyte adhesion will increase the rate of chorioamnionitis (chorio). We hypothesize that in the setting of preterm premature rupture of membranes (PPROM) prostaglandin inhibition prolongs latency and increases rates of chorio.
Methods
We performed a secondary analysis of women in two publically available data sets from the Maternal Fetal Medicine Units (MFMU) randomized controlled trials of ASA vs. placebo for PEC prevention. We also performed a subgroup analysis of women with preterm premature rupture of membranes (PPROM). Baseline demographic data were compared using Fisher’s exact and Wilcoxon as appropriate. Chi-square analysis compared incidence of chorio in the ASA and placebo groups. In the PPROM sub-analysis, length of latency was compared using Wilcoxon test.
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