Methods
Women with acute PID were enrolled in a randomized controlled trial of two outpatient PID treatment regimens (ceftriaxone and doxycycline +/- metronidazole). Cervical and endometrial samples, obtained at enrollment and at 30 days following treatment, were tested for Neisseria gonorrhoeae (GC), Chlamydia trachomatis (CT), and M. genitalium (MG) by NAAT. Histologic assessment for endometritis was assessed independently by 2 blinded pathologists with quantification of neutrophils and plasma cells to determine acute endometritis (>5 PMNs per 400X surface epithelium and > 1 plasma cell per 100X) and plasma cell endometritis (> 1 plasma cell per 100X).
Methods
Women with acute PID were enrolled in a randomized controlled trial of two outpatient PID treatment regimens (ceftriaxone and doxycycline +/- metronidazole). Cervical and endometrial samples, obtained at enrollment and at 30 days following treatment, were tested for Neisseria gonorrhoeae (GC), Chlamydia trachomatis (CT), and M. genitalium (MG) by NAAT. Histologic assessment for endometritis was assessed independently by 2 blinded pathologists with quantification of neutrophils and plasma cells to determine acute endometritis (>5 PMNs per 400X surface epithelium and > 1 plasma cell per 100X) and plasma cell endometritis (> 1 plasma cell per 100X).
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