Methods
We conducted a secondary cohort analysis of the publicly available, de-identified Maternal-Fetal Medicine Unit Cesarean Registry. Women undergoing an unlabored CD comprised the study cohort. Women with chorioamnionitis or who did not receive antibiotics were excluded. We defined the exposure as beta-lactam (penicillin or cephalosporin) or non-beta-lactam (gentamicin, clindamycin, other). Our primary composite outcome included wound infection, seroma, hematoma, endometritis, maternal hospital readmission due to a wound complication, and need for wound debridement. Logistic regression models estimated odds of composite outcome by antibiotic regimen after adjustment for maternal demographic, clinical and delivery characteristics. Backwards stepwise method was used to determine confounders and those with p<0.05 were included. Pre-gestational diabetes, smoking and skin incision were included as confounders a priori. We performed a planned subgroup analysis of women with class 3 obesity (BMI ≥ 40 kg/m2) at delivery.
Methods
We conducted a secondary cohort analysis of the publicly available, de-identified Maternal-Fetal Medicine Unit Cesarean Registry. Women undergoing an unlabored CD comprised the study cohort. Women with chorioamnionitis or who did not receive antibiotics were excluded. We defined the exposure as beta-lactam (penicillin or cephalosporin) or non-beta-lactam (gentamicin, clindamycin, other). Our primary composite outcome included wound infection, seroma, hematoma, endometritis, maternal hospital readmission due to a wound complication, and need for wound debridement. Logistic regression models estimated odds of composite outcome by antibiotic regimen after adjustment for maternal demographic, clinical and delivery characteristics. Backwards stepwise method was used to determine confounders and those with p<0.05 were included. Pre-gestational diabetes, smoking and skin incision were included as confounders a priori. We performed a planned subgroup analysis of women with class 3 obesity (BMI ≥ 40 kg/m2) at delivery.
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