15 | Prevention of Infections |
Infection Risks and Countermeasures
The risk of infection associated with invasive procedures, such as venipuncture, bladder catheter, surgical interventions, delivery, depends on the virulence of the pathogen (both obligatory or facultative pathogens) and on the germ count, in particular.
The majority of infections after surgical intervention are caused by facultative pathogens originating from the patient herself. These pathogens are normally present at low counts in the external genital region and on the skin of every person.
Whether or not this will lead to an infection depends primarily on how many germs are introduced into the wound, on the growth conditions the germs find there, and on the response of the body’s immune system.
By using prophylactic procedures with respect to nursing or hygiene, and also by antibiotic prophylaxis, the number of bacteria can be kept so low that the infection risk remains low as well.
No single method can achieve complete absence of germs in regions of the skin, intestines, and genitals—only a reduction in the number of germs. As far as that goes, the various procedures of disinfection, catheter hygiene, and wound care will have to supplement antibiotic prophylaxis and therapy.
Venipuncture and Maintenance of a Venous Catheter
Disinfection of the skin. The skin needs to be disinfected chemically and mechanically. High-proof alcohol solutions are commonly used to degrease the skin and inactivate bacteria. Since spores are able to survive in 70% alcohol, mixtures of 60% isopropyl alcohol and antiseptics like phenyl-phenol have gained acceptance.
Just spraying the skin area with disinfectant is not good enough. The commercially available spray pumps should only serve to moisten the swab, which is then used for rubbing the disinfectant into the skin.
Every time an indwelling catheter is put in place, the disinfectant needs to be applied several times (for two to four minutes), since the inactivation of bacteria depends on the time of application.
Since the body is able to deal with low numbers of bacteria introduced, this is not so important during the usual collection of blood from immunocompetent patients.
However, the situation is quite different when applying an indwelling (intravenous) catheter. These plastic catheters may become contaminated with coagulase-negative staphylococci, especially Staphylococcus epidermidis. Less common is a contamination with Candida or Enterobacteriaceae, such as Pseudomonas aeruginosa.
Especially coagulase-negative staphylococci are able to adhere to the polymer surface of the catheter, where they multiply and produce an extracellular mucous substance, thus protecting themselves against immune defenses and antibiotics. The bacteremia originating from the catheter tip may then lead to chronic sepsis (catheter sepsis).
A peripheral venous catheter should therefore only be applied after careful disinfection and under aseptic conditions. It should not stay in place for longer than 24–48 hours, at the most.
Central venous catheters, which are supposed to remain for several days, must be applied with special care and under strictly aseptic conditions with surgical covering.
Any venous catheter put in place in an emergency should be changed after 12 hours, at the latest.
Disinfection Prior to Surgical Interventions
There is no ideal disinfectant for the mucosa. So far, polyvidone–iodine proved to be the most suitable agent. It is marketed in alcoholic form for the disinfection of skin. This normal solution should be diluted when used for disinfection of the vagina. The time of application should be at least five minutes. Chlorohexidine is another effective antiseptic.
One should keep in mind that all disinfection procedures reduce only the amount of germs on the surface, and that a considerable number of microbes will recolonize the skin within a short time (hours).
The removal of hairs before surgical interventions has to take place immediately before the surgery. This is achieved either by wet shaving or a hair removal cream. Shaving of the surgical area on the day before surgery is not permitted as this would increase the number of germs and, hence, the risk of infection.
Wound Drainage
After abdominal or vaginal hysterectomy, the vaginal stump should not be closed completely. Insertion of a T-tube for 24 hours permits the drainage of wound secretion without increasing the risk of ascending microbes. The insertion of a gauze strip (tamponade) promotes the multiplication of germs more than insertion of a drainage tube.
The tamponade should not remain in place for more than 24 hours, preferably less.
Any subfascial Redon drainage should stay in place as short as possible, normally not longer than 24 hours, preferably less.
If the drainage needs to remain for a longer period in the abdominal cavity or in the tissue, the drainage opening should be carefully covered with sterile material, and it should be repeatedly disinfected. It is also important to make sure that there is no backflow of secretion. At the first signs of an infection, early antibiotic treatment with a drug effective against staphylococci is advised, and the drainage tube should be removed soon.
Wound Care
After vaginal hysterectomy and vaginoplasty, it is not uncommon that the high numbers of bacteria present in the vagina lead to superficial infection of the wound area, which is further promoted by necrotic tissue and wound secretion. Early rinsing of the wound with a 1:100 dilution of the polyvidone–iodine solution reduces the number of germs and promotes healing.
Sitting baths are largely obsolete and only suitable for superficial wounds. Because of the macerating effect, the duration of a sitting bath should be short. Astringent bath additives, such as tanning agents (Tannolact), yield better results.
Skin infections (e.g., at the suprapubic incision) should be opened early and, depending on the pathogen, rinsed once or twice daily with polyvidone–iodine (Staphylococcus aureus) or with hydrogen peroxide (anaerobic bacteria).
The germ-reducing effect of these procedures lasts only for a few hours.
Urinary Diversion
Ascending infections due to an indwelling transurethral catheter are very common. After eight days, about 70–90 % of catheterized women exhibit bacteriuria. This may turn into symptomatic cystitis and may also cause bacteria to ascend further. If urinary diversion is supposed to last for more than three days, one should always attempt suprapubic catheterization. The rate of bacteriuria is much lower here, namely, only about 20% after five days. Even after 10 days, the rate increases only to about 30% if the site of the cutaneous incision is being cared for properly.
Approach:
careful disinfection of the urethra prior to catheterization
transurethral catheters should stay in place as short as possible; in case of simple interventions, they should be removed once the an esthesia subsides—after 24 hours, at the latest
if a longer stay is required, suprapubic catheterization is advised
closed diversion systems, which do not lead to reflux of urine, should be used.
Prophylaxis of Bacterial Infections
The introduction of antibiotic prophylaxis for patients undergoing hysterectomy and cesarean section has reduced the infection risk by a factor of three to four.
Objective for antibiotic prophylaxis. Whether or not antibiotic prophylaxis should be used depends also on the frequency of infections in the individual clinic.
When deciding whether or not to use antibiotics for preventing infections, one should be guided by the type of intervention as well as the patient’s condition. Patients who suffer from several systemic diseases—such as diabetes mellitus, obesity, and suspected immunodeficiency (age, cancer, AIDS, condition after transplantation)—should always receive antibiotics even if the intervention is minor.
In principle, it is safer to use antibiotic prophylaxis. Of course, it may not prevent all infections, particularly not late infections.
In addition to preventing the more common but mild infections, which nevertheless may bother the patient, the main purpose is to reduce the rare but serious infectious complications that occasionally lead to death and occur almost exclusively in patients who have undergone surgery without antibiotic prophylaxis. These cases then tend to be called “fateful events.”
The type of the antibiotic used as well as the duration of prophylaxis are of secondary importance, the purpose of prophylaxis being to reduce the germs in the surgical area to such an extent that no infection will occur in the deeper regions.
The antibiotic used does not need to be effective against all potential microbes, since it is frequently the synergism between aerobic and anaerobic microbes that leads to wound infection and, finally, sepsis.
Thus, a considerable reduction in postoperative infections has also been achieved by using substances effective only against aerobes, or those effective only against anaerobes.
The duration of prophylaxis is also of secondary importance. In today’s view, a high level of antibiotic at the time of surgery is all that is required. Antibiotic prophylaxis for more than 24 hours, or even for three or five days, has been abandoned because it does not yield better results and, apart from higher costs, carries the risk of microbial selection.
Likewise, the half-life of the antibiotic used is of secondary importance. Nevertheless, there is a slight difference in the frequency of, for example, urinary tract infections. The rate is lower for an antibiotic with a long half-life (e.g., ceftriaxone) than for an antibiotic with a comparable spectrum but a half-life of only one hour (e.g., cefotiam).