CEREBRAL PERFUSION PRESSURE (CPP)
Formula: CPP = Mean Arterial Pressure (MAP) − Intracranial Pressure (ICP)
Infants: 40 mmHg
Adults: 65 mmHg
Changes throughout development: parallels changes in systemic blood pressure (BP); increases gradually throughout development to adult levels.
Consider patient’s baseline BP: Baseline MAP should be considered when considering therapeutic target for CPP in setting of acute neurologic injury. A patient with baseline hypertension will need blood pressure supported to a level that approximates their baseline physiology.
In adults poor outcomes are associated with sustained CPP <40 mmHg.