Lateral Ventricular Mass
Bernadette L. Koch, MD
DIFFERENTIAL DIAGNOSIS
Common
Choroid Plexus Cyst
Intraventricular Hemorrhage (IVH)
Less Common
Subependymal Giant Cell Astrocytoma
Ependymal Cyst
Choroid Plexus Papilloma
Rare but Important
Choroid Plexus Carcinoma
Meningioma
Langerhans Cell Histiocytosis
Central Neurocytoma
Subependymoma
Ependymoma
ESSENTIAL INFORMATION
Helpful Clues for Common Diagnoses
Choroid Plexus Cyst
Key facts
Most common intraventricular mass in children and adults
Any age; adults > > children
Frequently bilateral
Lateral ventricle > > > 3rd ventricle
Imaging findings
Cyst within or attached to choroid plexus
CE cyst wall and surrounding choroid
Hyperintense FLAIR and DWI common
± irregular peripheral calcifications
Xanthogranuloma = laden degenerative cyst; more common in adults
Intraventricular Hemorrhage (IVH)
Key facts
2° to germinal matrix hemorrhage, trauma, tumor, or vascular malformation
Imaging findings
Intraventricular hemorrhage initially hyperechoic and hyperdense
± dependent fluid-fluid level
± clotted blood adherent to choroid plexus
May → ventriculitis &/or hydrocephalus
Post-traumatic IVH: Frequently with SAH, and usually sequelae of severe injury
Helpful Clues for Less Common Diagnoses
Subependymal Giant Cell Astrocytoma
Key facts
Present in 15% of patients with tuberous sclerosis complex
Imaging findings
Heterogeneously enhancing mass near foramen of Monro
± calcifications
+ intraparenchymal hamartomas
± obstructive hydrocephalus
± globe hamartomas
Enhancement alone does not allow discrimination from hamartoma
Growth suggests subependymal giant cell astrocytoma rather than hamartoma
MRS: Less than expected ↓ NAA due to neuronal elements in tumor
Ependymal Cyst
Key facts
Synonym: Neuroepithelial cyst
Congenital, benign ependymal-lined cyst
Intraventricular, central WM of temporoparietal and frontal lobes, subarachnoid space, mesencephalon
Imaging findings
Lateral ventricle > > > 3rd and 4th ventricle
Nonenhancing, thin-walled cyst
Round or multiseptated
Similar to CSF on all imaging
± hyperintensity on T2WI and FLAIR
Choroid Plexus Papilloma
Key facts
Lateral > 3rd and 4th ventricle in children
4th ventricle most common site in adults
Usually < 1 year of age at diagnosis
Males > > > females
Rarely bilateral
Usually present with hydrocephalus secondary to obstruction, CSF overproduction by tumor or hemorrhage impaired CSF resorption
Differentiation from choroid plexus carcinoma is histologic, not radiologic
Imaging findings
Helpful Clues for Rare Diagnoses
Choroid Plexus Carcinoma
Key facts
≈ always in lateral ventricle
Usually 3-5 years of age
Males = females
Usually present with hydrocephalus ± focal neurological deficits related to local brain invasion
Imaging findings
Heterogeneous mass with irregular margins + parenchymal invasion ± surrounding edema
Cysts, hemorrhage, and necrosis common
MRS: Absent NAA and Cr/PhCr peak; higher choline peak than papilloma + increased lactate
± CSF metastasis
Meningioma
Key facts
Lateral ventricle atrium most common site; left > right
Uncommon in children; consider NF2
Pediatric meningiomas: More frequently large, cystic, rapidly growing, and malignant vs. adult disease
Imaging findings
Lobular, intensely enhancing intraventricular mass
± calcification ± cysts, hemorrhage
Heterogeneity or indistinct margins favor higher degrees of malignancy
Langerhans Cell Histiocytosis
CNS involvement = pituitary infundibulum, parenchymal, dural, or choroid plexusStay updated, free articles. Join our Telegram channel
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