Hypertension
Kevin E.C. Meyers
INTRODUCTION
Normotension is defined as blood pressure (BP) (systolic, diastolic, or both) that is <90th percentile for the patient’s age, height percentile, and sex. Prehypertension is defined as BP levels ≥90th percentile but <95th percentile. Hypertension is defined as average systolic and/or diastolic BP ≥95th percentile for gender, age, and height on three or more separate occasions (readings).
Stage 1 hypertension is the designation for BP levels that range from ≥95th percentile to 5 mm Hg ≥99th percentile.
Stage 2 hypertension is the designation for BP levels >5 mm Hg above the 99th percentile.
Hypertensive urgency is severely elevated BP with no evidence for secondary end-organ damage.
Hypertensive emergency is severely elevated BP with clinical evidence for endorgan damage (retinopathy, papilledema, encephalopathy, seizures, gastrointestinal bleed, cardiac failure, or renal insufficiency).
Labile blood pressure refers to BP (systolic, diastolic, or both) that is sometimes above and sometimes below the 95th percentile and does not result in hypertensive damage to organs. Labile BP is frequently found in teenagers. White coat hypertension is present when elevated BP readings are found in a medical setting with normal BPs measured elsewhere. Masked hypertension is present when the BP is normal or prehypertensive in the office but elevated when measured elsewhere (often confirmed by 24-hour ambulatory BP monitoring).
The prevalence of hypertension in the pediatric population is estimated to be between 1% and 5%. Younger children are more likely to have an underlying cause for hypertension than adolescents and adults. However, primary (essential) hypertension is now seen in children and adolescents and is associated with obesity, metabolic syndrome, and a family history of hypertension.
DIFFERENTIAL DIAGNOSIS LIST
Primary Hypertension (Essential Hypertension)
Monogenetic Causes
Gordon syndrome
Liddle syndrome
Syndrome of apparent mineralocorticoid excess
Glucocorticoid remediable aldosteronism
Renoparenchymal Causes
Glomerulonephritis—acute and chronic
Hemolytic uremic syndrome
Focal segmental glomerulosclerosis
Lupus nephritis
Pyelonephritis (acute or chronic) or reflux nephropathy
Polycystic kidney disease—autosomal recessive, autosomal dominant
Wilms tumor
Obstructive uropathy
Trauma
Vascular Causes
Coarctation of the aorta
Large arteriovenous fistula
Mid-aortic syndrome (idiopathic, Williams syndrome, NF-1, tuberous sclerosis, Takayasu arteritis)
Renal artery stenosis (fibromuscular dysplasia)
Renal artery thrombosis
Renal venous thrombosis
Endocrine Causes
Cushing syndrome
Hyperthyroidism or hypothyroidism
Hyperparathyroidism
Pheochromocytoma
Neuroblastoma
Congenital adrenal hyperplasia
Conn syndrome (hyperaldosteronism)
Neurologic Causes
Traumatic brain injury
Intracranial hemorrhage (epidural, subdural, subarachnoid)
Increased intracranial pressureStay updated, free articles. Join our Telegram channel
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