Hypertension



Hypertension


Kevin E.C. Meyers



INTRODUCTION

Normotension is defined as blood pressure (BP) (systolic, diastolic, or both) that is <90th percentile for the patient’s age, height percentile, and sex. Prehypertension is defined as BP levels ≥90th percentile but <95th percentile. Hypertension is defined as average systolic and/or diastolic BP ≥95th percentile for gender, age, and height on three or more separate occasions (readings).



  • Stage 1 hypertension is the designation for BP levels that range from ≥95th percentile to 5 mm Hg ≥99th percentile.


  • Stage 2 hypertension is the designation for BP levels >5 mm Hg above the 99th percentile.


  • Hypertensive urgency is severely elevated BP with no evidence for secondary end-organ damage.


  • Hypertensive emergency is severely elevated BP with clinical evidence for endorgan damage (retinopathy, papilledema, encephalopathy, seizures, gastrointestinal bleed, cardiac failure, or renal insufficiency).

Labile blood pressure refers to BP (systolic, diastolic, or both) that is sometimes above and sometimes below the 95th percentile and does not result in hypertensive damage to organs. Labile BP is frequently found in teenagers. White coat hypertension is present when elevated BP readings are found in a medical setting with normal BPs measured elsewhere. Masked hypertension is present when the BP is normal or prehypertensive in the office but elevated when measured elsewhere (often confirmed by 24-hour ambulatory BP monitoring).

The prevalence of hypertension in the pediatric population is estimated to be between 1% and 5%. Younger children are more likely to have an underlying cause for hypertension than adolescents and adults. However, primary (essential) hypertension is now seen in children and adolescents and is associated with obesity, metabolic syndrome, and a family history of hypertension.




DIFFERENTIAL DIAGNOSIS LIST


Primary Hypertension (Essential Hypertension)


Monogenetic Causes



  • Gordon syndrome


  • Liddle syndrome


  • Syndrome of apparent mineralocorticoid excess


  • Glucocorticoid remediable aldosteronism


Renoparenchymal Causes



  • Glomerulonephritis—acute and chronic


  • Hemolytic uremic syndrome


  • Focal segmental glomerulosclerosis


  • Lupus nephritis


  • Pyelonephritis (acute or chronic) or reflux nephropathy


  • Polycystic kidney disease—autosomal recessive, autosomal dominant


  • Wilms tumor


  • Obstructive uropathy


  • Trauma


Vascular Causes



  • Coarctation of the aorta


  • Large arteriovenous fistula


  • Mid-aortic syndrome (idiopathic, Williams syndrome, NF-1, tuberous sclerosis, Takayasu arteritis)


  • Renal artery stenosis (fibromuscular dysplasia)


  • Renal artery thrombosis


  • Renal venous thrombosis


Endocrine Causes



  • Cushing syndrome


  • Hyperthyroidism or hypothyroidism


  • Hyperparathyroidism


  • Pheochromocytoma


  • Neuroblastoma


  • Congenital adrenal hyperplasia


  • Conn syndrome (hyperaldosteronism)


Neurologic Causes

Sep 14, 2016 | Posted by in PEDIATRICS | Comments Off on Hypertension

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