Objectives
Previable preterm premature rupture of membranes (PPPROM) typically has a poor maternal and neonatal prognosis, and a shorter latency period worsens outcomes. A paucity of data regarding factors associated with longer latency after PPPROM makes management decisions and patient counseling challenging. We sought to examine maternal clinical factors associated with reaching viability among women with PPPROM.
Methods
From 2000-2014, a single institution retrospective cohort study of women carrying singleton or twin pregnancies complicated by midtrimester PPROM (14.0-21.9 weeks gestation), without clinical chorioamnionitis, who elected expectant pregnancy management and achieved at least 24 hours latency. Pregnancies with fetal anomalies, higher order multiples, or PPROM within 2 weeks of CVS/amniocentesis were excluded. Maternal characteristics and other clinical factors were compared among those pregnancies that reached fetal viability (≥23.0 weeks) and those delivering before viability (<23.0 weeks), using chi-square, Fisher’s exact, or t-test, as appropriate.
Methods
From 2000-2014, a single institution retrospective cohort study of women carrying singleton or twin pregnancies complicated by midtrimester PPROM (14.0-21.9 weeks gestation), without clinical chorioamnionitis, who elected expectant pregnancy management and achieved at least 24 hours latency. Pregnancies with fetal anomalies, higher order multiples, or PPROM within 2 weeks of CVS/amniocentesis were excluded. Maternal characteristics and other clinical factors were compared among those pregnancies that reached fetal viability (≥23.0 weeks) and those delivering before viability (<23.0 weeks), using chi-square, Fisher’s exact, or t-test, as appropriate.
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