Methods
This study is retrospective cohort from a single institution from 2000-2014 with singleton or twin pregnancies complicated by PPPROM at 14.0-22.9 weeks, without chorioamnionitis at presentation, who elected expectant management and achieved at least 24 hours latency. Pregnancies with fetal anomalies, higher order multiples, PPPROM within 2 weeks of CVS/amniocentesis, or delayed interval twin deliveries were excluded. The primary outcome was any infant in the pregnancy surviving to hospital discharge. Of those pregnancies that delivered ≥ 23 weeks, we also examined composite major neonatal morbidity (grade III/IV intraventricular hemorrhage, necrotizing enterocolitis, bronchopulmonary dysplasia, pulmonary hypoplasia, and/or death prior to discharge) and death prior to discharge of any infant in the pregnancy. Twin outcomes were compared to singleton outcomes using chi-square, Fisher’s exact, t-test, and Wilcoxon rank-sum as appropriate.
Methods
This study is retrospective cohort from a single institution from 2000-2014 with singleton or twin pregnancies complicated by PPPROM at 14.0-22.9 weeks, without chorioamnionitis at presentation, who elected expectant management and achieved at least 24 hours latency. Pregnancies with fetal anomalies, higher order multiples, PPPROM within 2 weeks of CVS/amniocentesis, or delayed interval twin deliveries were excluded. The primary outcome was any infant in the pregnancy surviving to hospital discharge. Of those pregnancies that delivered ≥ 23 weeks, we also examined composite major neonatal morbidity (grade III/IV intraventricular hemorrhage, necrotizing enterocolitis, bronchopulmonary dysplasia, pulmonary hypoplasia, and/or death prior to discharge) and death prior to discharge of any infant in the pregnancy. Twin outcomes were compared to singleton outcomes using chi-square, Fisher’s exact, t-test, and Wilcoxon rank-sum as appropriate.
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