Treatment and Medical Management of Children with Autism Spectrum Disorders



Treatment and Medical Management of Children with Autism Spectrum Disorders


Eileen M. Costello

Elizabeth B. Caronna





  • I. Description of the problem.



    • A. Treatment of core symptoms of autism spectrum disorders. Primary care providers are expected to help families make decisions about the management of a child with autism spectrum disorders (ASD). Because the spectrum is wide and includes a range of ability and disability, there is no one management strategy that works for all affected children. There is a growing body of research that supports the use of specific educational interventions as the foundation of therapy for ASD. However, individual children with ASD have variable responses to therapy, and there is regional variation in quality and quantity of available services. As a result, many families utilize a wide variety of therapies, both proven and unproven, in an attempt to treat both the core features of autism (deficits in verbal and nonverbal communication, impairment in social interactions, and restricted interests or repetitive behaviors) and the many associated difficulties commonly seen in children with ASD, such as deficits in sensory processing, sleep disturbance, gastrointestinal complaints, seizures, and anxiety or depression. (See Chapter 26 on Autism Spectrum Disorders and Chapter 24 on Asperger Syndrome in this volume for more information.) Pediatric providers should have a general familiarity with the strengths and limitations of both widely accepted and unconventional treatments for ASD and be able to steer parents toward evidence-based therapies available in the community whenever possible. (See as well Chapter 27 on Complementary and Alternative Medicine in Autism Spectrum Disorders in this volume.)


    • B. Medical and psychiatric comorbidities. The primary care provider should be alert to common medical comorbidities in ASD and for signs of medical symptoms that may be obscured by, or difficult to assess because of, the symptoms of ASD. For example, changes in behaviors of children with ASD (such as self-injury or aggression) may be attributed to worsening symptoms of ASD, causing an underlying medical disorder unrelated to ASD (such as gastroesophageal reflux or a dental abscess) to be missed. Challenges of history taking and detailed physical examination in the nonverbal or noncompliant child with ASD may compound this problem. Psychopharmacologic management, although not demonstrated to improve the core deficits in autism, can be helpful in managing some associated symptoms.


  • II. Educational interventions. Intensive educational and behavioral programs have the best track record for improving outcomes of children with autism. As soon as a child is diagnosed with an ASD, immediate enrollment in an intensive educational or behavioral program is indicated. For children younger than 3 years, rapid referral for Early Intervention Services is crucial. Consensus statements from experts from both the educational/psychological and the medical fields recommend that Early Intervention should include active engagement of the child using a structured, consistent approach for a minimum of 25 hours per week, 12 months per year, with as much one-on-one engagement as possible. After the age of 3 years, services are typically provided through the public school system. Family training, in which parents learn to apply the educational and behavioral techniques in use during the school day, is a critical element of any program. Most research has focused on effectiveness of interventions with young children, but these interventions are also the foundation of instruction of older children, teens, and adults with ASD.

    Three main types of educational interventions have been described. Each has unique components as well as components shared with the other two. Which therapy “works” for a child is determined by family preference, regional availability of qualified therapists, and the child’s characteristics. With some children, there must be some “trial and error” before an effective individualized educational program is realized. Although no single therapy can be recommended above all others based on available evidence, it is clear that intensive services provided by skilled therapists with expertise in working with children with ASD are critical for success. The rate of progress depends on both the quality of the therapy provided and on
    the child’s learning style and intellectual level. However, with appropriate instruction, all children with ASD can be expected to make demonstrable progress over time.



    • A. Applied behavioral analysis (ABA). ABA is a systematic and structured approach to instruction based on the science of behavior and learning which utilizes observation, data collection, and positive reinforcement to teach communication, academic, and social skills and to reduce problem behaviors. ABA can be used in both structured and naturalistic settings by skilled therapists, and programs such as Pivotal Response Training and Verbal Behavior Therapy also are grounded in the theories of ABA. Instruction based on ABA is widely used in preschool- and school-aged children, but the cost of one-on-one instruction of the intensity recommended in most studies can be prohibitively expensive. Coverage of the cost of these services through medical insurance and educational systems varies both by state and locally, but there are growing efforts by advocacy groups to mandate coverage of ABA and other therapies through medical insurance. ABA is the best studied of the educational approaches for ASD.


    • B. Structured teaching. The Treatment and Education of Autistic and related Communication-handicapped Children (TEACCH) program is the most prominent example of structured teaching for children with ASD. This method “structures” the physical environment and teaching techniques using visual supports and a predictable routine. The use of visual schedules fosters a predictable sequence of daily activities and structures activities. The emphasis of this method is on improving skills and modifying the environment to adapt to the learning preferences and needs of children with ASD.


    • C. Developmental approaches.



      • 1. Developmental, Individual Difference Relationship-based model (DIR). The focus is on “Floortime” sessions of play of parent or therapist with the child to enhance relationships and foster emotional, social, and cognitive growth through developmentally appropriate play that taps the child’s strengths. This therapy is directed at building “biologically based processing capacities” including auditory processing and language, motor planning and sequencing, visual-spatial processing, and sensory modulation.


      • 2. Relationship Development Intervention (RDI) is designed to use positive reinforcement through a systematic, parent-based intervention to promote interactive behaviors that engage the child in a social relationship, first with an adult, and then with peers.


      • 3. Social Communication/Emotional Regulation/Transactional Supports (SCERTS). The SCERTS model combines elements of the programs described above to promote social communication initiated by the child. It is typically used in classrooms and is well-suited to inclusive classroom settings.


    • D. Other interventions directed at specific aspects of ASD.



      • 1. Alternative Communication Strategies. Many children with ASD have stronger visual than verbal reasoning abilities, so a variety of visual supports are commonly used in home and school settings. Alternative communication uses a range of simple to technologically advanced tools such as sign language, objects, photos, drawings, and computer-based technologies. It is most important for preverbal or nonverbal children.


      • 2. The Picture Exchange Communication System (PECS) is in wide use. In this system, a child initiates a request by using a small picture of something he desires (such as a food or a toy) in exchange for the item. This system incorporates ABA and developmental principles and is effective with many children.


      • 3. Visual supports such as the pictures or icons used in PECS can also be used in other ways, such as providing visual schedules, supporting vocabulary development, and for behavioral management strategies.


      • 4. Speech and language therapy. The majority of children with ASD will require speech and language therapy to address their deficits in expressive and receptive language and social communication. Most children with ASD benefit from both individual and group speech and language therapy. There is evidence to support the use of pragmatic language therapy, which focuses on using language for social interaction, rather than the production of speech.

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Jun 22, 2016 | Posted by in PEDIATRICS | Comments Off on Treatment and Medical Management of Children with Autism Spectrum Disorders

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