Unplanned or unintended pregnancy remains a significant challenge for adolescents; many teens who plan ahead but opt not to choose long-acting reversible contraceptive methods have high failure rates with condom usage, oral contraceptives, and other less long-acting methods. Emergency contraception (EC) remains a necessity for those adolescents seeking a second chance to prevent the unintended consequences of unplanned sexual activity. At present, 5 postcoital methods remain available as EC globally: intrauterine devices, ulipristal acetate, a selective progesterone modulator, mifepristone; levonorgestrel, and ethinyl estradiol plus levonorgestrel or norgestrel (rarely used now that progestin only methods are more readily available).
Key points
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Emergency contraception (EC) needs to be available, accessible, and proactively prescribed and/or discussed with adolescents before the need to use it.
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Counseling about EC does not result in increased sexual activity and can actively help prevent adolescent pregnancies.
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The copper T intrauterine device works very well and provides so-called forgettable contraception for up to 10 years after insertion.
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Ulipristal acetate is less expensive and has efficacy up to 5 days after intercourse, compared with levonorgestrel EC, with efficacy for up to 72 hours after unplanned intercourse.
Introduction
Emergency contraception (EC) is defined as any medication or device used to reduce the risk of pregnancy after unprotected or inadequately protected sexual intercourse. EC is intended as an emergency rescue measure in women who have had unprotected intercourse or a failure of another contraceptive method and is not intended to be used as a primary contraceptive method. In the United States, there are 4 currently approved methods of EC, including the copper intrauterine device (IUD) and 3 oral methods: ulipristal acetate (UPA), levonorgestrel, and the Yuzpe method (ethinyl estradiol plus levonorgestrel). Internationally, mifepristone is also approved in some countries for the purposes of EC. Compared with adults, adolescents are more likely to use contraception intermittently or ineffectively. In addition, adolescents are more likely than adults to use less effective forms of contraception. Thus, sexually active adolescents are at high risk for unwanted or unplanned pregnancy compared with adults and are an important target for EC education and usage. Usage of EC in adolescents greatly improves if they receive counseling and prescriptions for usage before any need arises ( Table 1 ).
Method (Trade Name) | Mechanism of Action | Benefits | Side Effects | Contraindications/Considerations | Efficacy; Failure Rate (%) | Access | Cost ($) |
---|---|---|---|---|---|---|---|
Copper IUD (Paragard) | Prevents sperm motility to prevent fertilization | No hormone; can remain in place as contraception for 10 y | Heavier bleeding and/or cramping | Pregnancy, pelvic infection, allergy to copper | 2.00 | Must be placed by physician | 500–932 |
UPA (Ella One) | Prevents or delays ovulation | Dose does not decline over time; 1-time dosing; side effects much less than estrogen-containing methods | Nausea and vomiting | Less effective in women with BMI>30 and ineffective in those with BMI>35, still more effective than levonorgestrel in this population | 1.80 | Requires prescription | 33–36 |
Mifepristone (RU486) | Prevents or delays ovulation and affects endometrial development | Dose does not decline over time; 1-time dosing | Nausea and vomiting; cramping; bleeding | Abortifacient at high doses | 2.19 | Requires prescription; only available in certain countries | — |
Levonorgestrel (Plan B, Plan B One-Step, Next Choice) | Prevents or delays ovulation | 1-time dosing; side effects much less than estrogen-containing methods | Nausea and vomiting | Less effective with BMI>25 and ineffective for BMI>30 with failure rate of 5.8% | 0.6–3.1 | Available OTC | 33–36 |
Ethinyl estradiol + levonorgestrel (Yuzpe method) | Prevents or delays ovulation | Widely available | Nausea and vomiting | Multiple doses with numerous pills; most side effects of all EC methods | — | Requires prescription | — |
Introduction
Emergency contraception (EC) is defined as any medication or device used to reduce the risk of pregnancy after unprotected or inadequately protected sexual intercourse. EC is intended as an emergency rescue measure in women who have had unprotected intercourse or a failure of another contraceptive method and is not intended to be used as a primary contraceptive method. In the United States, there are 4 currently approved methods of EC, including the copper intrauterine device (IUD) and 3 oral methods: ulipristal acetate (UPA), levonorgestrel, and the Yuzpe method (ethinyl estradiol plus levonorgestrel). Internationally, mifepristone is also approved in some countries for the purposes of EC. Compared with adults, adolescents are more likely to use contraception intermittently or ineffectively. In addition, adolescents are more likely than adults to use less effective forms of contraception. Thus, sexually active adolescents are at high risk for unwanted or unplanned pregnancy compared with adults and are an important target for EC education and usage. Usage of EC in adolescents greatly improves if they receive counseling and prescriptions for usage before any need arises ( Table 1 ).
Method (Trade Name) | Mechanism of Action | Benefits | Side Effects | Contraindications/Considerations | Efficacy; Failure Rate (%) | Access | Cost ($) |
---|---|---|---|---|---|---|---|
Copper IUD (Paragard) | Prevents sperm motility to prevent fertilization | No hormone; can remain in place as contraception for 10 y | Heavier bleeding and/or cramping | Pregnancy, pelvic infection, allergy to copper | 2.00 | Must be placed by physician | 500–932 |
UPA (Ella One) | Prevents or delays ovulation | Dose does not decline over time; 1-time dosing; side effects much less than estrogen-containing methods | Nausea and vomiting | Less effective in women with BMI>30 and ineffective in those with BMI>35, still more effective than levonorgestrel in this population | 1.80 | Requires prescription | 33–36 |
Mifepristone (RU486) | Prevents or delays ovulation and affects endometrial development | Dose does not decline over time; 1-time dosing | Nausea and vomiting; cramping; bleeding | Abortifacient at high doses | 2.19 | Requires prescription; only available in certain countries | — |
Levonorgestrel (Plan B, Plan B One-Step, Next Choice) | Prevents or delays ovulation | 1-time dosing; side effects much less than estrogen-containing methods | Nausea and vomiting | Less effective with BMI>25 and ineffective for BMI>30 with failure rate of 5.8% | 0.6–3.1 | Available OTC | 33–36 |
Ethinyl estradiol + levonorgestrel (Yuzpe method) | Prevents or delays ovulation | Widely available | Nausea and vomiting | Multiple doses with numerous pills; most side effects of all EC methods | — | Requires prescription | — |
Epidemiology
Despite decreases in the rate of teen births over the past 50 years in the United States, the teen birth rate remains high compared with other industrialized nations. In addition, 82% of pregnancies in girls aged 15 to 19 years are unplanned or unintended. Thus, adolescents represent an important target group for education not only about ongoing contraceptive options but also in the use of EC after unprotected intercourse, contraceptive failure, or sexual assault. The benefits of EC, in addition to preventing unintended pregnancy, also extend to related consequences of adolescent motherhood, including premature birth, stunted educational and vocational opportunities, decreased rates of high school completion, increased welfare dependence and future poverty rates, decreased psychological functioning, and decreased employment stability.
Pregnancy risk
Ovulation usually occurs between days 10 and 21 of the menstrual cycle, most commonly between days 13 and 16. However, because adolescents are more likely to have irregular and/or anovulatory cycles, it is harder to predict when ovulation will occur. The fertile period is estimated to last about 6 days, beginning about 5 days before ovulation. Once an ovum is released, it has 24 hours to be fertilized by a spermatozoon. Spermatozoa remain viable in the female reproductive tract for 5 to 6 days and can fertilize an ovum on release from the ovaries during this time period.
Following a single act of intercourse at an unknown point in the menstrual cycle, there is a 4% to 6% risk of pregnancy. However, during the most fertile time of the cycle (starting 5 days before ovulation and ending 24 hours after ovulation), this risk increases to approximately a 30% risk of becoming pregnant following a single encounter of vaginal intercourse. Given the uncertainty of timing of ovulation, especially in adolescents, and the prolonged viability of sperm, EC should be encouraged in the setting of contraceptive failure at any point throughout the menstrual cycle. Adolescents suspected to require EC in the fertile window of the menstrual cycle may benefit from one of the more effective methods of EC, such as a copper IUD or UPA.

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