Risk of Asthma in Children with Early Wheezing
Max Rubinstein
Benjamin A. Nelson
Asthma and Wheezing in the First Six Years of Life. The Group Health Medical Associates
Martinez FD, Wright AL, Taussig LM, et al. N Engl J Med. 1995;332(3):133–138
Background
In the US, up to 1/3 of children will have at least 1 wheezing episode by age 3.1 To improve discussions surrounding prognosis and treatment with families, a better understanding of both the pathogenesis and correlation of early wheezing to asthma development was needed. This study was one of the first to follow children longitudinally from infancy onward.
Objectives
To document the natural history of early childhood wheezing and identify predictors for future development of asthma.
Methods
Prospective cohort study in a single US center from 1980 to 1990.
Patients
826 children enrolled at birth in the Tucson Children’s Respiratory Study and who completed follow-up at 3 and 6 years. Select exclusion criteria: none.
Intervention
Baseline family characteristics were collected at enrollment, with follow-up questionnaires regarding symptoms of wheeze and allergic rhinitis. Children were evaluated for all respiratory illness(es). Immunoglobulin E (IgE) levels, pulmonary function tests, and skin testing were obtained within the first year and at 6 years.
Stay updated, free articles. Join our Telegram channel
Full access? Get Clinical Tree
