Perinatal infections are a significant cause of fetal and neonatal mortality and an important contributor to early and later childhood morbidity. The TORCH acronym originally grouped five pathogens with similar clinical findings. TORCH refers to toxoplasmosis, other agents, (syphilis, etc.), rubella, Cytomegalovirus (CMV), and herpes simplex virus (HSV). Over time, many microbes, including human immunodeficiency virus (HIV), parvovirus B19, and enteroviruses, have been placed into the TORCH acronym. Although the term is useful in generating a differential diagnosis, the indiscriminate use of TORCH “titers” or battery as a diagnostic tool has limited utility due to low yield, difficulty in interpreting single serum samples. Furthermore, more sensitive and specific methods now exist to diagnose perinatal infections. In one study of almost 1,200 TORCH screens, only 1.4% were positive and only 0.7% were associated with confirmed disease.