Principles of Antiparasitic Therapy

Chapter 271 Principles of Antiparasitic Therapy




Parasites are divided into 2 main groups taxonomically: protozoans, which are unicellular, and helminths, which are multicellular. Chemotherapeutic agents appropriate for 1 group may not be appropriate for the other, and not all drugs are readily available. Some drugs are available only from the manufacturer, some are not available in the USA, and some are available through the Centers for Disease Control and Prevention Drug Service (telephone: 404-639-3670, weekdays; 404-639-2888, evenings, weekends, and holidays) image(see Tables 271-1 and 271-2 on the Nelson Textbook of Pediatrics website at www.expertconsult.com).





Table 271-2 MANUFACTURERS OF DRUGS USED TO TREAT PARASITIC INFECTIONS







*Antiminth (Pfizer)—pyrantel pamoate

Aralen (Sanofi)—chloroquine HCl and chloroquine phosphate

*artemether—Artenam (Arenco, Belgium)

*Artenam (Arenco, Belgium)—artemether

*artesunate—(Guilin No. 1 Factory, People’s Republic of China)




Bactrim (Roche)—TMP/Sulfa

*benznidazole—Rochagan (Roche, Brazil)


*Biltricide (Bayer)—praziquantel

bithionol—Bitin (Tanabe, Japan)

Bitin (Tanabe, Japan)—bithionol

*Brolene (Aventis, Canada)—propamidine isethionate chloroquine HCl and chloroquine phosphate—Aralen (Sanofi), others


Cleocin (Pfizer)—clindamycin






diethylcarbamazine citrate USP—Hetrazan


*diloxanide furoate—Furamide (Boots, U.K.)


eflornithine (difluoromethylornithine, DFMO)—Ornidyl (Aventis)

*Egaten (Novartis)—triclabendazole





Flagyl (Searle)—metronidazole


Fungizone (Apothecon)—amphotericin

*Furamide (Boots, U.K.)—diloxanide furoate

*furazolidone—Furozone (Roberts)

*Furozone (Roberts)—furazolidone

Germanin (Bayer, Germany)—suramin sodium

*Glucantime (Aventis, France)—meglumine antimoniate

Hetrazan—diethylcarbamazine citrate USP


*Impavido (Zentaris, Germany)—miltefosine





Jun 18, 2016 | Posted by in PEDIATRICS | Comments Off on Principles of Antiparasitic Therapy

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