Pneumomediastinum
Daniel J. Podberesky, MD
DIFFERENTIAL DIAGNOSIS
Common
Asthma
Straining against Closed Glottis
Aspiration
Blunt Chest Trauma
Iatrogenic
Surfactant Deficiency Disease
Pulmonary Interstitial Emphysema
Less Common
Infection
Extension of Pneumoperitoneum or Pneumoretroperitoneum
Rare but Important
Esophageal Tear
ESSENTIAL INFORMATION
Key Differential Diagnosis Issues
Potential sources for pneumomediastinum
Trachea and bronchi
Lung
Esophagus
Pleural space
Head/neck
Peritoneal space
Retroperitoneal space
Helpful radiographic signs in pneumomediastinum
Thymic sail sign: Elevation of thymus by large amount of pneumomediastinum
Continuous diaphragm: Air trapped posterior to pericardium
Ring around artery sign: Air surrounding pulmonary artery branch
Air in inferior pulmonary ligament: Retrocardiac extension of pneumomediastinum
Double wall sign: Intramural gas along proximal airways
Associated pneumothorax, pneumopericardium, or subcutaneous emphysema
Pneumomediastinum is frequently asymptomatic and self-limited
History is extremely helpful in determining possible source of pneumomediastinum
Is there trauma history?
Is there history of recent instrumentation?
Is the patient asthmatic?
Helpful Clues for Common Diagnoses
Asthma
Airway narrowing and mucous plugging leads to air-trapping and alveolar rupture
History of asthma exacerbation helpful in making diagnosis
Hyperinflated lungs
Straining against Closed Glottis
History helpful
Vomiting
Giving birth to child
Weight-lifting
No specific imaging features
Aspiration
Results from air-trapping and alveolar rupture
Meconium aspiration
History of meconium-stained amniotic fluid helpful
Coarse interstitial and patchy opacities
Hyperinflation
Foreign body aspiration
Peanuts most common in children
Frequency of right vs. left bronchial tree involvement is equal in young children
Right > left bronchial tree involvement in older children and adults
Unilateral hyperinflation
Atelectasis
Decubitus views can be helpful if radiolucent foreign body is suspected
Blunt Chest Trauma
History helpful
Motor vehicle crash
Fall
Sports injury
Alveolar rupture &/or tracheobronchial injury
Other signs of trauma
Fractures
Pulmonary contusions
Mediastinal injuries
Pleural effusions
Iatrogenic
Mechanical ventilation
Instrumentation can result in
Tracheobronchial injury
Esophageal injury
Postoperative patients
History helpful
Surfactant Deficiency Disease
Premature neonates
Reticulogranular opacities
Air leak from alveolar rupture can lead to pneumomediastinum
Pulmonary Interstitial Emphysema
Premature infants
Barotrauma from mechanical ventilation
Reticular and cystic opacities
Alveolar rupture with air leak into pulmonary interstitium
Can progress to pneumomediastinum and pneumothorax
Helpful Clues for Less Common Diagnoses
Infection
Mycoplasma pneumonia
Common cause of community-acquired pneumonia in children
Typically good prognosis
Typically reticulonodular opacities
Can be complicated by alveolar destruction and rupture leading to pneumomediastinum
Pneumocystis pneumonia
History helpful
AIDS-defining illness
Bilateral ground-glass and reticulonodular opacities
Can result in parenchymal lung cysts, which can rupture and lead to pneumomediastinumStay updated, free articles. Join our Telegram channel
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