Placentomegaly
Roya Sohaey, MD
DIFFERENTIAL DIAGNOSIS
Common
Hydrops
Acute Placental Abruption
Macrosomia
Twins
Less Common
Battledore Placenta
Intrauterine Growth Restriction (IUGR)
Rare but Important
Triploidy
ESSENTIAL INFORMATION
Key Differential Diagnosis Issues
Normal placenta is < 40 mm thick
Placenta grows approximately 1 mm/wk
10 wk placenta = 10 mm
20 wk placenta = 20 mm
30 wk placenta = 30 mm
Evaluate placental attachment
Normal attachment
Hydrops
Macrosomia
Diabetes
IUGR
Small attachment
Battledore placenta
Heterogeneous attachment
Abruption
Evaluate placental morphology
Increased sonolucencies
Triploidy
IUGR
Focal thickening
Dichorionic twins
Focal abruption
Large thin placenta
Monochorionic twins
Heterogeneous thick placenta
Abruption
IUGR
Use Doppler to assess placental function
Uterine artery Doppler
Low resistive flow in second trimester
Post systolic notch abnormal > 18 wks
Umbilical artery (UA) Doppler
Low resistive flow after 2nd trimester
Absent diastolic flow abnormal > 16 wks
Systolic/diastolic ratio < 3.0 if > 30 wks
Reversed diastolic flow always abnormal
Fetal middle cerebral artery (MCA) Doppler
Higher resistive flow than UA
Severe IUGR leads to ↓ resistance
Use MCA peak systolic velocity to assess for fetal anemia
Insonation angle is important
0° angle on MCA
Use normogram to compare with gestational age
↑ Velocity suggests anemia
Helpful Clues for Common Diagnoses
Hydrops
Excessive fetal body fluid
Skin edema
Pleural effusion
Ascites
Pericardial effusion
Hydrops if ↑ fluid in 2 areas
Amniotic fluid findings variable
Polyhydramnios
Oligohydramnios
Placenta edema
More likely if immune hydrops
Common causes of nonimmune hydrops
Infection
Aneuploidy (Turner most common)
Heart failure
Fetal anemia of any etiology
Acute Placental Abruption
Acute blood has same echogenicity as placenta
Mimics thick placenta
Becomes hypoechoic with time
Direct hemorrhage into placenta can occur
Most common with retroplacental abruption
Arterial hemorrhage
Use power Doppler
No flow in hematoma
> 50% detachment associated with > 50% fetal death
Macrosomia
Definition
Estimated fetal weight > 90th percentile
Birthweight > 4500 g
Causes
Hereditary
Diabetes
Beckwith-Wiedemann (BW)
Polyhydramnios
Both hereditary causes and diabetes associated with ↑ fluid
Impaired swallowing if macroglossia and BW
Twins
Dichorionic twins may have appearance of single large placental mass
“Twin peak” or “delta” signs are focal point where 2 placentas meet
Thick membrane (4 layers) extends from “peak” or “delta”
Large thin placenta of monochorionic twinning
No triangular peak
Thin membrane (two layers)
Helpful Clues for Less Common Diagnoses
Battledore Placenta
Thick placenta with small attachment
↑ Risk for abruption
Marginal cord insertion site
Within 2 cm of placental margin
At risk for becoming velamentous
Intrauterine Growth Restriction (IUGR)
Estimated fetal weight < 10th percentile
Variable placenta appearance