Acute gastroenteritis is estimated to account for >1.5 million outpatient visits and 200,000 hospitalizations in the US annually.¹ Oral rehydration therapy (ORT) for mild-to-moderate dehydration has been recommended both by the Centers for Disease Control and Prevention and the American Academy of Pediatrics, but physicians are sometimes hesitant to initiate oral fluids and medications in an actively vomiting patient.^1,2 Prior to this study, there were limited data on the benefit of adding the antiemetic ondansetron as an adjunct to ORT in the acute setting.

To determine if administration of a single oral disintegrating tablet (ODT) of ondansetron decreases vomiting or improves clinical outcomes in children with gastroenteritis receiving ORT for mild-to-moderate dehydration.