Chapter 211 Nonvenereal Treponemal Infections Stephen K. Obaro, H. Dele Davies Nonvenereal treponemal infections—yaws, bejel (endemic syphilis), and pinta—are caused by different subspecies of Treponema pallidum and occur in tropical and subtropical areas. The causative agents of nonvenereal treponematoses—T. pertenue, T. pallidum subspecies endemicum, and T. carateum—cannot be distinguished from T. pallidum by morphologic or serologic tests. These diseases are characterized by a relapsing clinical course and prominent skin involvement. Penicillin remains the treatment of choice for syphilis and nonvenereal treponemal infections. 211.1 Yaws (Treponema pertenue) Stephen K. Obaro and H. Dele Davies Yaws is the most prevalent nonveneral treponematosis. It is a contagious, chronic, relapsing infection involving the skin and bony structures caused by the spirochete T. pertenue, which is identical to T. pallidum microscopically and serologically. It occurs in tropical regions with heavy rainfall and annual temperatures ≥27°C (80°F). Almost all cases occur in children in tropical and subtropical countries. It is also referred to as “framboesia,” “pian,” “parangi,” and “bouba.” A high percentage of the population is infected in endemic areas. T. pertenue is transmitted by direct contact from an infected lesion through a skin abrasion or laceration. Transmission is facilitated by overcrowding and poor personal hygiene in the rain forest areas of the world. The initial papular lesion, which constitutes primary yaws, also described as the “mother yaw,” occurs 2-8 wk after inoculation. This lesion typically involves the buttocks or lower extremities. The papule develops into a raised, raspberry-like papilloma and is often accompanied by regional lymphadenopathy. Healing of the mother yaw leaves a hypopigmented scar. The secondary stage lesions can erupt anywhere on the body before or after the healing of the mother yaw and may be accompanied by lymphadenopathy, anorexia, and malaise. Multiple cutaneous lesions (daughter yaws, pianomas, or framboesias) appear, spread diffusely, ulcerate, and are covered by exudates containing treponemes. Secondary lesions heal without scarring. Recurrent lesions are common within 5 yr after the primary lesion. The lesions are often associated with bone pain resulting from underlying periostitis or osteomyelitis, especially of the fingers, nose, and tibia. The initial period of clinical activity is followed by a 5-10 yr period of latency. The appearance of tertiary stage lesions develops in approximately 10% of infected patients, with onset typically at puberty with solitary and destructive lesions. These lesions occur as painful papillomas on the hands and feet, gummatous skin ulcerations, or osteitis. Bony destruction and deformity, juxta-articular nodules, depigmentation, and painful hyperkeratosis (“dry crab yaws”) of the palms and soles are common. Only gold members can continue reading. Log In or Register to continue Share this: Share on X (Opens in new window) X Share on Facebook (Opens in new window) Facebook Related Related posts: Human T-Lymphotropic Viruses (1 and 2) Eosinophilic Gastroenteritis The Common Cold Cleft Lip and Palate Stay updated, free articles. Join our Telegram channel Join Tags: Nelson Textbook of Pediatrics Expert Consult Jun 18, 2016 | Posted by admin in PEDIATRICS | Comments Off on Nonvenereal Treponemal Infections Full access? Get Clinical Tree
Chapter 211 Nonvenereal Treponemal Infections Stephen K. Obaro, H. Dele Davies Nonvenereal treponemal infections—yaws, bejel (endemic syphilis), and pinta—are caused by different subspecies of Treponema pallidum and occur in tropical and subtropical areas. The causative agents of nonvenereal treponematoses—T. pertenue, T. pallidum subspecies endemicum, and T. carateum—cannot be distinguished from T. pallidum by morphologic or serologic tests. These diseases are characterized by a relapsing clinical course and prominent skin involvement. Penicillin remains the treatment of choice for syphilis and nonvenereal treponemal infections. 211.1 Yaws (Treponema pertenue) Stephen K. Obaro and H. Dele Davies Yaws is the most prevalent nonveneral treponematosis. It is a contagious, chronic, relapsing infection involving the skin and bony structures caused by the spirochete T. pertenue, which is identical to T. pallidum microscopically and serologically. It occurs in tropical regions with heavy rainfall and annual temperatures ≥27°C (80°F). Almost all cases occur in children in tropical and subtropical countries. It is also referred to as “framboesia,” “pian,” “parangi,” and “bouba.” A high percentage of the population is infected in endemic areas. T. pertenue is transmitted by direct contact from an infected lesion through a skin abrasion or laceration. Transmission is facilitated by overcrowding and poor personal hygiene in the rain forest areas of the world. The initial papular lesion, which constitutes primary yaws, also described as the “mother yaw,” occurs 2-8 wk after inoculation. This lesion typically involves the buttocks or lower extremities. The papule develops into a raised, raspberry-like papilloma and is often accompanied by regional lymphadenopathy. Healing of the mother yaw leaves a hypopigmented scar. The secondary stage lesions can erupt anywhere on the body before or after the healing of the mother yaw and may be accompanied by lymphadenopathy, anorexia, and malaise. Multiple cutaneous lesions (daughter yaws, pianomas, or framboesias) appear, spread diffusely, ulcerate, and are covered by exudates containing treponemes. Secondary lesions heal without scarring. Recurrent lesions are common within 5 yr after the primary lesion. The lesions are often associated with bone pain resulting from underlying periostitis or osteomyelitis, especially of the fingers, nose, and tibia. The initial period of clinical activity is followed by a 5-10 yr period of latency. The appearance of tertiary stage lesions develops in approximately 10% of infected patients, with onset typically at puberty with solitary and destructive lesions. These lesions occur as painful papillomas on the hands and feet, gummatous skin ulcerations, or osteitis. Bony destruction and deformity, juxta-articular nodules, depigmentation, and painful hyperkeratosis (“dry crab yaws”) of the palms and soles are common. Only gold members can continue reading. Log In or Register to continue Share this: Share on X (Opens in new window) X Share on Facebook (Opens in new window) Facebook Related Related posts: Human T-Lymphotropic Viruses (1 and 2) Eosinophilic Gastroenteritis The Common Cold Cleft Lip and Palate Stay updated, free articles. Join our Telegram channel Join Tags: Nelson Textbook of Pediatrics Expert Consult Jun 18, 2016 | Posted by admin in PEDIATRICS | Comments Off on Nonvenereal Treponemal Infections Full access? Get Clinical Tree
